91422-50-3Relevant academic research and scientific papers
Chiral Pool/Henry/Enzymatic routes to acetogenin synthons
Qayed, Wesam S.,Luzzio, Frederick A.
, p. 622 - 630 (2015/11/09)
Enantio specific and enantioselective approaches to the natural (16 R,19R)- and the unnatural (16S,19S)- THF core of the bioactive acetogenin annonacin are described which utilizes both a chiral pool synthesis and enzymatic transformations. In the antipodal (2S,5S) THF series derived from D-(+)-glucosamine, the semi-protected THF aldehyde synthon allows for two-directional synthetic elaboration through a Henry reaction with a lipid-like nitroalkane. The resulting nitroalcohol having the unnatural (2S,5S)-THF core was oxidized to the corresponding a-nitroketone using a modified Collins oxidation. The intermediate a-nitroketone has potential for the preparation of the C15-C32 core and analogues through subsequent removal of the nitro group and reduction of the carbonyl.
2,5-ANHYDRO-D-HEXITOLS: SYNTHESES OF 2,5-ANHYDRO-D-ALTRITOL AND 2,5-ANHYDRO-D-IDITOL
Otero, Dario A.,Simpson, Ronald
, p. 79 - 86 (2007/10/02)
2,5-Anhydro-D-altritol (2a) and the previously-unknown 2,5-anhydro-D-iditol (3a) have been prepared from 2,5-anhydro-D-mannitol (1a).The preparation of 3a from the intermediate epoxide 7b is particularly sensitive to pH, and a mechanism is proposed to explain this.Attention is drawn to the limitations of the trifluoroperacetic acid-disodium hydrogenphosphate procedure for the epoxidation of alkenes of diminished reactivity.
