914224-34-3

Basic information

• Product Name: 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol
• Synonyms: 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol;2-(4-nitrophenyl)iMidazo[2,1-b][1,3]benzothiazol-7-ol, 2-(4-nitrophenyl)iMidazo[2,1-b]benzothiazol-7-ol;2-(4-Nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-ol;Imidazo[2,1-b]benzothiazol-7-ol, 2-(4-nitrophenyl)-
• CAS NO: 914224-34-3
• Molecular Formula: C₁₅H₉N₃O₃S
• Molecular Weight: 311.31526
• Mol File: 914224-34-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.61g/cm³
• Refractive Index: 1.805
• CAS DataBase Reference: 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol(914224-34-3)
• EPA Substance Registry System: 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol(914224-34-3)

Safety Data

• Hazardous Substances Data: 914224-34-3(Hazardous Substances Data)

Usage

General Description

2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol is a chemical compound with the molecular formula C17H10N4O3S. It is a derivative of imidazo[2,1-b]benzothiazole and contains a nitrophenyl group. 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol has potential applications in medicinal and pharmaceutical research due to its unique structure and potential biological activities. The nitro group in the compound may provide interesting reactivity and properties, and it could be explored for its potential as a drug candidate or a precursor in organic synthesis. Its synthesis and properties make it a valuable compound for further investigation in various scientific fields.

InChI:InChI=1/C15H9N3O3S/c19-11-5-6-13-14(7-11)22-15-16-12(8-17(13)15)9-1-3-10(4-2-9)18(20)21/h1-8,19H

Upstream product

• 26278-79-5 2-amino-6-hydroxybenzothiazole 
• 99-81-0 4-Nitrophenacyl bromide 
• 106-51-4 p-benzoquinone 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 

Downstream Products

• 950769-74-1 7-(3-chloropropoxy)-2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazole 
• 950769-60-5 4-(2-((2-(4-nitrophenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethyl)morpholine 
• 1132827-30-5 4-(7-hydroxyimidazo[2,1-b]benzothiazol-2-yl)benzenamine 
• 1225542-42-6 7-(2-chloroethoxy)-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazolel 
• 950769-61-6 2-(4-aminophenyl)-7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazole 
• 950769-58-1 quizartinib 
• 1132827-21-4 Quizartinib dihydrochloride 
• 1300734-53-5 7-(2-morpholin-D₈-4-yl-ethoxy)-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole 

Relevant articles and documents

Benzo imidazo [2, 1-b] thiazole compound and application thereof (by machine translation)

The invention discloses a benzoimidazo [2, 1-b] thiazole compound and application thereof, and belongs to the technical field of medicines. The inhibitory activity of the synthesized benzimidazo [2, 1-b] thiazole analogues on FLTT3 is more than 90%, wherein the compounds (compounds 2 , 4, 6, 8 and 10) are IC of FLTT3-ITD kinase. 50 Lower value, in particular compound 2, IC IC50 The value is only 5.60 nm, and therefore the compound of the present invention may be used as an inhibitor FLTT3, or for preparing a drug capable of modulating or suppressing diseases associated with abnormal cell proliferation by affecting the enzymatic activity of one or more tyrosine kinases and interfering with aberrant cell proliferation, having a wide application prospect. (by machine translation)

PROCESS FOR THE PREPARATION OF IMIDAZO[2,1-B][1,3]BENZOTHIAZOLE DERIVATIVES

Provided herein are process for the preparation of N-(5-ferf-butyl-isoxazol-3-yl)- N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,l-fe][l,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof. N-(5-tert- Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,l-and][l,3]benzo- thiazol-2-yl]phenyl}urea is useful for treating, preventing, and/or managing diseases or conditions, including but not limited to, proliferative diseases, FLT-3 mediated diseases, and cancers. N-(5-ferf-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl- ethoxy)imidazo[2,l-and][l,3]benzothiazol-2-yl]phenyl}urea is represented by the structure:

IMIDAZOLOTHIAZOLE COMPOUNDS AS MODULATORS OF PROTEIN KINASE

Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.