914248-50-3Relevant academic research and scientific papers
1-Phenylprop-2-ynyl acetate: A useful building block for the stereoselective construction of polyhydroxylated chains
Ariza, Xavier,Garcia, Jordi,Georges, Yohan,Vicente, Mar
, p. 4501 - 4504 (2007/10/03)
(R)- or (S)-1-phenylprop-2-ynyl acetate was added stereoselectively to aldehydes to afford 4-hydroxy-1-phenylalk-2-ynyl acetates. The transformation of such adducts into the corresponding allylic 1,4-diacetates allowed a highly efficient transfer of chirality from C1 to C3 by a regio- and stereoselective [3,3]-sigmatropic rearrangement. The obtained unsaturated 1,2-diacetates were useful synthetic intermediates whose double bond and/or phenyl group were transformed in different aldehydes, acids, or esters.
