914299-32-4

Basic information

• Product Name: methyl 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-4-methylbenzoate
• Synonyms: methyl 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-4-methylbenzoate
• CAS NO: 914299-32-4
• Molecular Weight: 477.942
• Mol File: 914299-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-4-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-4-methylbenzoate(914299-32-4)
• EPA Substance Registry System: methyl 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-4-methylbenzoate(914299-32-4)

Safety Data

• Hazardous Substances Data: 914299-32-4(Hazardous Substances Data)

Upstream product

• 2840-04-2 5-amino-2-methylbenzoic acid 
• 54811-38-0 5-iodo-2-methylbenzoic?acid 
• 103440-54-6 methyl 5-iodo-2-methylbenzoate 
• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 1975-52-6 5-nitro-o-toluic acid 
• 939-83-3 2-cyano-4-nitrotoluene 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 914299-30-2 C₁₈H₂₅NO₄ 
• 914299-29-9 C₁₆H₂₂INO₂ 
• 914299-26-6 C₁₄H₁₄INO₂ 
• 914298-93-4 methyl 5-chloro-2,4-bis(methoxymethoxy)benzoate 
• 914298-92-3 methyl 2,4-dimethoxymethyloxybenzoate 
• 914299-27-7 C₁₁H₁₂IN 
• 914299-28-8 C₁₁H₁₄IN 

Downstream Products

• 914299-34-6 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide 
• 914299-33-5 C₂₃H₂₆ClNO₇ 

Relevant articles and documents

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone

Information from X-ray crystal structures were used to optimize the potency of a HTS hit in a Hsp90 competitive binding assay. A class of novel and potent small molecule Hsp90 inhibitors were thereby identified. Enantio-pure compounds 31 and 33 were potent in PGA-based competitive binding assay and inhibited proliferation of various human cancer cell lines in vitro, with IC50 values averaging 20 nM.