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Usage

Uses

Used in Pharmaceutical Industry:
3-(3-chlorophenyl)pyrrolidine(SALTDATA: FREE) is used as a reactant for the synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines, which are compounds with demonstrated antibacterial activity. These triazine derivatives are valuable in the development of new antimicrobial agents to combat bacterial infections.
Additionally, 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines also exhibit the ability to inhibit inorganic pyrophosphatase, an enzyme that plays a crucial role in various metabolic processes. The inhibition of this enzyme can have therapeutic implications in certain disease conditions, making 3-(3-chlorophenyl)pyrrolidine(SALTDATA: FREE) a significant intermediate in the creation of pharmaceuticals targeting such enzyme pathways.

InChI:InChI=1/C10H12ClN/c11-10-3-1-2-8(6-10)9-4-5-12-7-9/h1-3,6,9,12H,4-5,7H2

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 6768-21-4 diethyl m-chlorobenzylidenemalonate 
• 40877-44-9 3-(3-Chloro-phenyl)-3-cyano-propionic acid ethyl ester 
• 66041-28-9 2-(3-chlorophenyl)succinic acid 
• 74208-83-6 3-(3-chlorophenyl)pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

The Titanium-Mediated Double Reductive Cleavage of Cyclic Sulfonamides for the Synthesis of Aryl Pyrrolidines

Reduction of a range of benzo-fused cyclic sulfonamides has been accomplished using low-valent titanium. This operationally simple method generates the corresponding aryl-substituted cyclic amines, typically, with good conversion. Notably, unlike our previous Li-NH3-based method, loss of heteroatom-based substituents (X) on the aromatic ring does not readily occur, and the robustness of this method was demonstrated with a synthesis of the Sceletium alkaloid mesembrane.

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

Inorganic pyrophosphatases are potential targets for the development of novel antibacterial agents. A pyrophosphatase-coupled high-throughput screening assay intended to detect o-succinyl benzoic acid coenzyme A (OSB CoA) synthetase inhibitors led to the unexpected discovery of a new series of novel inorganic pyrophosphatase inhibitors. Lead optimization studies resulted in a series of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazine derivatives that were prepared by an efficient synthetic pathway. One of the tetracyclic triazine analogues 22h displayed promising antibiotic activity against a wide variety of drug-resistant Staphylococcus aureus strains, as well as activity versus Mycobacterium tuberculosis and Bacillus anthracis, at a concentration that was not cytotoxic to mammalian cells.