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Usage

Uses

Used in Pharmaceutical Development:
1-Boc-6-methyl-3-formylindole is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Research:
In the agrochemical industry, 1-Boc-6-methyl-3-formylindole is utilized as a starting material for the creation of novel agrochemicals. Its structural properties enable the design of compounds with improved pesticidal or herbicidal activities.
Used in Materials Science:
1-Boc-6-methyl-3-formylindole is employed as a building block in the development of new materials with specific properties. Its versatility in organic synthesis allows for the creation of materials with tailored characteristics for various applications in science and industry.
Overall, 1-Boc-6-methyl-3-formylindole's potential applications span across multiple industries, including pharmaceuticals, agrochemicals, and materials science, due to its unique structural features and reactivity in organic synthesis. Its synthesis and functionalization have been extensively studied, highlighting its importance in medicine and other scientific fields.

InChI:InChI=1/C15H17NO3/c1-10-5-6-12-11(9-17)8-16(13(12)7-10)14(18)19-15(2,3)4/h5-9H,1-4H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 4771-49-7 6-methyl-1H-indole-3-carboxaldehyde 

Relevant academic research and scientific papers

Structure-guided design, synthesis, and biological evaluation of (2-(1 H-Indol-3-yl)-1 H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) methanone (ABI-231) analogues targeting the colchicine binding site in Tubulin

ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. Guided by the crystal structure of ABI-231 in complex with tubulin, we performed structure-activity relationship studies around the 3-indole moiety that led to the discovery of several potent ABI-231 analogues, most notably 10ab and 10bb. The crystal structures of 10ab and 10bb in complex with tubulin confirmed their improved molecular interactions to the colchicine site. In vitro, biological studies showed that new ABI-231 analogues disrupt tubulin polymerization, promote microtubule fragmentation, and inhibit cancer cell migration. In vivo, analogue 10bb not only significantly inhibits primary tumor growth and decreases tumor metastasis in melanoma xenograft models but also shows a significant ability to overcome paclitaxel resistance in a taxane-resistant PC-3/TxR model. In addition, pharmacological screening suggested that 10bb has a low risk of potential off-target function.

Indole-substituted hydrazide derivatives and uses thereof

The invention discloses indole-substituted hydrazide derivatives and a use thereof, concretely relates to novel indole-substituted hydrazide derivatives and a medicinal composition including the abovecompounds, a use of the derivatives and the medicinal composition in the protection of nerve cells, and also relates to a method for preparing the compounds and the medicinal composition, and a use of the compounds and the medicinal composition in the preparation of drugs for treating diseases associated with glutamate excitotoxicity and oxidative stress damage or free radicals, or neurodegenerative diseases, especially the Alzheimer disease.