914349-08-9 Usage
General Description
1-Boc-3-hydroxymethyl-6-methoxyindole, also known as 6-Methoxy-3-indolylmethyl 1-carboxylate, is a chemical compound with a molecular formula of C15H17NO4. It is a synthetic derivative of indole that is often used in the pharmaceutical industry as an intermediate for the synthesis of various bioactive compounds. 1-Boc-3-hydroxymethyl-6-methoxyindole has been studied for its potential therapeutic applications, particularly in the treatment of neurological disorders and cancer. It has also shown promise as a building block for the development of new drugs and as a reagent in organic synthesis. Additionally, 1-Boc-3-hydroxymethyl-6-methoxyindole has been investigated for its potential use in agrochemicals and as a precursor for natural product synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 914349-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,3,4 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 914349-08:
(8*9)+(7*1)+(6*4)+(5*3)+(4*4)+(3*9)+(2*0)+(1*8)=169
169 % 10 = 9
So 914349-08-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H19NO4/c1-15(2,3)20-14(18)16-8-10(9-17)12-6-5-11(19-4)7-13(12)16/h5-8,17H,9H2,1-4H3
914349-08-9Relevant articles and documents
Asymmetric Total Synthesis of Sarpagine and Koumine Alkaloids
He, Ling,Jiang, Yan,Qiao, Zhen,Qiu, Hanyue,Su, Xiaojiao,Tan, Qiuyuan,Yang, Jiaojiao,Yang, Zhao,Zhang, Min,Zhou, Wenqiang
, p. 13105 - 13111 (2021)
We report here a concise, collective, and asymmetric total synthesis of sarpagine alkaloids and biogenetically related koumine alkaloids, which structurally feature a rigid cage scaffold, with L-tryptophan as the starting material. Two key bridged skeleton-forming reactions, namely tandem sequential oxidative cyclopropanol ring-opening cyclization and ketone α-allenylation, ensure concurrent assembly of the caged sarpagine scaffold and installation of requisite derivative handles. With a common caged intermediate as the branch point, by taking advantage of ketone and allene groups therein, total synthesis of five sarpagine alkaloids (affinisine, normacusine B, trinervine, Na-methyl-16-epipericyclivine, and vellosimine) with various substituents and three koumine alkaloids (koumine, koumimine, and N-demethylkoumine) with more complex cage scaffolds has been accomplished.
