914349-52-3 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(2-Aminopyrimidin-5-yl)benzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form different derivatives and analogs with potential therapeutic properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(2-Aminopyrimidin-5-yl)benzaldehyde is utilized as a structural component in the development of new drugs, given its capacity to participate in a range of chemical reactions that can lead to the creation of novel bioactive molecules.
Used in Drug Discovery:
2-(2-Aminopyrimidin-5-yl)benzaldehyde is employed as a starting material in drug discovery, where its unique structure and reactivity are leveraged to explore new chemical entities with potential applications in treating various diseases and conditions.
Used in Organic Compounds Synthesis:
In organic chemistry, 2-(2-Aminopyrimidin-5-yl)benzaldehyde is used as a precursor to synthesize a variety of organic compounds, taking advantage of its reactive aldehyde group and the versatility of the 2-aminopyrimidin-5-yl substituent.
Check Digit Verification of cas no
The CAS Registry Mumber 914349-52-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,3,4 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 914349-52:
(8*9)+(7*1)+(6*4)+(5*3)+(4*4)+(3*9)+(2*5)+(1*2)=173
173 % 10 = 3
So 914349-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H9N3O/c12-11-13-5-9(6-14-11)10-4-2-1-3-8(10)7-15/h1-7H,(H2,12,13,14)
914349-52-3Relevant academic research and scientific papers
Hauke, Tobias J.,Wein, Thomas,H?fner, Georg,Wanner, Klaus T.
, p. 10310 - 10332 (2018)
This study describes the screening of dynamic combinatorial libraries based on nipecotic acid as core structure with substituents attached to the 5- instead of the common 1-position for the search of novel inhibitors of the GABA transporter GAT1. The generated pseudostatic hydrazone libraries included a total of nearly 900 compounds and were screened for their binding affinities toward GAT1 in competitive mass spectrometry (MS) based Binding Assays. Characterization of the hydrazones with the highest affinities (with cis-configured rac-16gf bearing a 5-(1-naphthyl)furan-2-yl residue and a four atom spacer being the most potent) in binding and uptake experiments revealed an allosteric interaction at GAT1, which was not reported for any other nipecotic acid derivative up to now. Therefore, the herein introduced 5-substituted nipecotic acid derivatives could serve as valuable tools for investigations of allosterically modulated GABA transport mediated by GAT1 and furthermore as starting point for a new class of GAT1 inhibitors.
