914390-91-3Relevant academic research and scientific papers
Palladium-Catalyzed Dearomative Cyclocarbonylation by C-N Bond Activation
Yu, Hui,Zhang, Guoying,Huang, Hanmin
, p. 10912 - 10916 (2015)
A fundamentally novel approach to bioactive quinolizinones is based on the palladium-catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I2], which features a very large bite angle, has been found to facilitate the rapid carbonylation of azaarene-substituted allylamines into bioactive quinolizinones in good to excellent yields. This transformation represents the first dearomative carbonylation and is proposed to proceed by palladium-catalyzed C-N bond activation, dearomatization, CO insertion, and a Heck reaction.
