914394-64-2

Basic information

• Product Name: 4-(2-fluoroethoxy)-3-methoxybenzaldehyde
• Synonyms: 4-(2-fluoroethoxy)-3-methoxybenzaldehyde
• CAS NO: 914394-64-2
• Molecular Weight: 198.194
• Mol File: 914394-64-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(2-fluoroethoxy)-3-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-fluoroethoxy)-3-methoxybenzaldehyde(914394-64-2)
• EPA Substance Registry System: 4-(2-fluoroethoxy)-3-methoxybenzaldehyde(914394-64-2)

Safety Data

• Hazardous Substances Data: 914394-64-2(Hazardous Substances Data)

Upstream product

• 383-50-6 2-fluoroethyl tosylate 
• 121-33-5 vanillin 
• 762-49-2 2-fluoroethyl bromide 
• 17792-74-4 4-methylbenzenesulfonic acid [(4-formyl-2-methoxyphenoxy)ethyl] ester 
• 99070-23-2 4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde 

Downstream Products

• 1012885-00-5 C₂₀H₂₄ClFN₂O₂ 
• 1012884-92-2 C₂₁H₂₇FN₂O₃ 
• 1335093-90-7 (E)-1-(2-fluoroethoxy)-2-methoxy-4-(2-nitrovinyl)benzene 
• 1335093-52-1 7-(2-fluoroethoxy)-1-(4-(2-fluoroethoxy)-3-methoxybenzyl)-6-methoxyisoquinoline 
• 1335093-44-1 1-(5-bromo-2-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline 
• 1335093-49-6 1-(4-fluoro-3-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline 
• 1335093-48-5 1-(3,5-dimethoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline 
• 1335093-47-4 7-(2-fluoroethoxy)-1-(3-(2-fluoroethoxy)-4-methoxybenzyl)-6-methoxyisoquinoline 
• 1335093-46-3 1-(3-fluorobenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline 
• 1335093-45-2 1-(3-bromo-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline 
• 1335093-43-0 1-(2-fluoro-4-methoxybenzyl)-7-(2-fluoroethoxy)-6-methoxyisoquinoline 
• 1335093-42-9 7-(2-fluoroethoxy)-6-methoxy-1-(4-(methylthio)benzyl)isoquinoline 
• 1335093-41-8 7-(2-fluoroethoxy)-6-methoxy-1-(4-methoxy-3-methylbenzyl)-isoquinoline 
• 1335093-94-1 2-(4-(2-fluoroethoxy)-3-methoxyphenyl)-2-methoxyethanamine 

Relevant articles and documents

Synthesis and characterization of 18F-labeled hydrazinocurcumin derivatives for tumor imaging

Fluorine-substituted hydrazinocurcumin derivative 1 and its dimethyl-substituted form at the C2 and C6 positions (2) were synthesized and their radiolabeled forms, [18F]1 and [18F]2, were evaluated for tumor imaging. In vitro and in vivo metabolism studies showed that the two radioligands were resistant to reductive metabolism, probably due to the presence of a pyrazole ring. In cellular uptake studies, [18F]1 and [18F]2 exhibited comparable uptake by human umbilical vascular endothelial cells and rat C6 glioma cells. Inhibition of radioligand uptake to a similar extent by HC and curcumin suggests that these radioligands may share the same binding sites as those for HC and curcumin. Positron emission tomography imaging of C6 glioma xenografted mice acquired 30 and 60 min after radioligand injection showed that [18F]2 had markedly higher tumor uptake than [18F]1, which was consistent with biodistribution data (3.20 ± 0.35% ID per g vs. 0.98 ± 0.31% ID per g, respectively). However, the two radioligands showed similar levels of tumor-to-background uptake ratio, except for the significantly higher uptake of [18F]1 by the small intestine, indicating its more rapid clearance. The results of this study will guide further structural modifications of these radioligands to enhance tumor-to-background uptake ratios.

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A

A series of analogues were synthesized by optimizing the structure of papaverine. The in vitro PDE10A binding affinity (IC50) values for these new analogues were measured; for compounds that have IC50 value less than 60 nM for PDE10A

IMIDAZOL [1,2-A] PYRIDINES AND RELATED COMPOUNDS WITH ACTIVITY AT CANNABINOID CB2 RECEPTORS

Disclosed are compounds of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof; and methods of modulating the activity of a cannabinoid CB2 receptor comprising contacting a compound of Formula (I) or Formula (II) with the cannabinoid CB2 receptor. Said compounds are useful in the treatment of various condition and disorders such as pain, and neurodegenerative disorders.