91441-48-4

Usage

Uses

Antineoplastic.

InChI:InChI=1/C21H25N5O4/c1-22-6-7-24-12-2-3-13-17-16(12)21(30)19-15(29)5-4-14(28)18(19)20(17)25-26(13)10-8-23-9-11-27/h2-5,22-24,27-29H,6-11H2,1H3

Upstream product

• 105158-36-9 2-<2-<(2-hydroxyethyl)(phenylmethyl)amino>ethyl>-5-<<2-ethyl>amino>-7,10-bis(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 91441-59-7 5-chloro-2-[2-[(2-hydroxyethyl)amino]ethyl]-7,10-bis(phenylmethoxy)anthra[1,9-cd]-pyrazol-6(2H)-one 
• 105167-87-1 5-chloro-2-<2-<(2-hydroxyethyl)(phenylmethyl)amino>ethyl>-7,10-bis-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 104740-31-0 2-<2-<(2-hydroxyethyl)amino>ethyl>-5-<<2-ethyl>amino>-7,10-bis(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 104740-10-5 (2-{7,10-Dihydroxy-2-[2-(2-hydroxy-ethylamino)-ethyl]-6-oxo-2,6-dihydro-dibenzo[cd,g]indazol-5-ylamino}-ethyl)-methyl-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride

Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI-937, CI-941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of t

Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

Chromophore modification of the anthracenediones related to mitoxantrone in an attempt to provide agents with diminished or no cardiotoxicity has resulted in a novel class of DNA binders, the anthrapyrazoles. Their synthesis was carried out by a two-stage

Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones

Substituted anthra[1,9-cd]pyrazol-6(2H-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed.