91444-85-8Relevant articles and documents
Nodulisporic acid A synthetic studies. 2. Construction of an eastern hemisphere subtarget.
Smith 3rd.,Cho,Ishiyama
, p. 3971 - 3974 (2001)
In this, the second of two Letters, we describe an effective assembly of (+)-4, an eastern hemisphere subtarget comprising the FGH rings of (+)-nodulisporic acid A (1) (17 steps, 9% overall yield). Central to the synthesis is a Koga three-component conjug
Development of a scalable synthesis of a common eastern tricyclic lactone for construction of the nodulisporic acids
Smith III, Amos B.,Kuerti, Laszlo,Davulcu, Akin H.,Cho, Young Shin
, p. 19 - 24 (2012/12/26)
A scalable, second-generation synthesis of the densely functionalized eastern tricyclic lactone (+)-6, a common intermediate, for construction of the nodulisporic acids has been achieved. Modifications to the first-generation route now permit access to (+
Regio- and stereoselective functionalizations of the Wieland-Miescher ketone derivatives at the C-8 position
Shimizu, Takeshi,Hiranuma, Sayoko,Yoshioka, Hirosuke
, p. 1963 - 1965 (2007/10/02)
New efficient methods for stereoselective hydroxymethylation, hydroxylation, and thiophenylation at the C-8 position of the Wieland-Miescher ketone derivatives (2-4) have been developed by diverse modifications from the Kirk-Petrow reaction, which involve autoxidation for the hydroxylation.Keywords - Wieland-Miescher ketone; Kirk-Petrow reaction; phenylthio-methylation; hydroxylation; hydroxymethylation; thiophenylation.