914458-31-4 Usage
Description
(5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)Methanone, also known as JWH 368, is a (1-naphthoyl)pyrrole cannabinoid (CB) that potently activates both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors (Ki values of 16 and 9.1 nM, respectively). Its physiological, neurological, and toxicological properties have not been evaluated. (5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)Methanone is intended for forensic and research applications.
Used in Forensic Applications:
(5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)Methanone is used as a forensic tool for the detection and analysis of synthetic cannabinoids in various samples, such as blood, urine, and hair.
Used in Research Applications:
(5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)Methanone is used as a research chemical to study the effects and mechanisms of action of synthetic cannabinoids on CB1 and CB2 receptors, as well as their potential therapeutic applications.
Used in Pharmaceutical Industry:
(5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl)(naphthalen-1-yl)Methanone is used as a starting compound for the development of new drugs targeting the cannabinoid receptors, which may have potential therapeutic benefits in various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 914458-31-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,4,5 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 914458-31:
(8*9)+(7*1)+(6*4)+(5*4)+(4*5)+(3*8)+(2*3)+(1*1)=174
174 % 10 = 4
So 914458-31-4 is a valid CAS Registry Number.
914458-31-4Relevant articles and documents
1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors
Huffman, John W.,Padgett, Lea W.,Isherwood, Matthew L.,Wiley, Jenny L.,Martin, Billy R.
, p. 5432 - 5435 (2007/10/03)
Two series of 1-alkyl-2-aryl-4-(1-naphthoyl)pyrroles were synthesized and their affinities for the cannabinoid CB1 and CB2 receptors were determined. In the 2-phenyl series (5) the N-alkyl group was varied from n-propyl to n-heptyl. A second series of 23 1-pentyl-2-aryl-4-(1-naphthoyl)-pyrroles (6) was also prepared. Several compounds in both series have CB1 receptor affinities in the 6-30 nM range. The high affinities of these pyrrole derivatives relative to JWH-030 (1, R = C5H11) support the hypothesis that these pyrroles interact with the CB1 receptor primarily by aromatic stacking.
