91447-90-4

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-chloro-2,6-dioxo-3H-pyrimidine-4-carboxylate is used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic benefits.
Used in Antimicrobial and Antifungal Applications:
Methyl 5-chloro-2,6-dioxo-3H-pyrimidine-4-carboxylate is studied for its potential as an antimicrobial and antifungal agent. Its ability to target and inhibit the growth of harmful microorganisms makes it a valuable asset in the development of new treatments for infectious diseases.
Used in Medicinal Chemistry Research:
As a derivative of pyrimidine, methyl 5-chloro-2,6-dioxo-3H-pyrimidine-4-carboxylate is utilized in medicinal chemistry research to explore its potential pharmacological properties. Its unique structure and reactivity provide opportunities for the discovery of new drug candidates and therapeutic agents.

InChI:InChI=1/C6H5ClN2O4/c1-13-5(11)3-2(7)4(10)9-6(12)8-3/h1H3,(H2,8,9,10,12)

Upstream product

• 6153-44-2 2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid methyl ester 
• 6153-44-2 methyl orotate 

Downstream Products

• 89284-85-5 2,5,6-trichloro-pyrimidine-4-carboxylic acid methyl ester 
• 502142-81-6 6-amino-2,5-dichloro-pyrimidine-4-carboxylic acid methyl ester 
• 183204-74-2 Tipiracil 
• 73742-45-7 5-chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione 
• 944128-95-4 2,6-dibromo-5-chloropyrimidine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Preparation method of 5-chloro-6-chloromethyluracil

The invention provides a 5-chloro-6-chloromethyl-uracil and a preparation method thereof. The method comprises the following steps: esterifying the 6-position carboxylic acid of orotic acid used as an initial raw material, chlorinating the 5-position hydrogen, reducing the 6-position ester into a hydroxymethyl group, and carrying out a chlorination substitution reaction to obtain the target product. The preparation method has the advantages of simplicity in operation, stable process, high yield and low cost, and is suitable for industrial production.

Tipracil intermediate, and preparation methods of tipracil intermediate, tipracil and tipracil hydrochloride

The invention relates to the field of medicine synthesis, in particular to a pyrimidine type derivative, particularly a tipracil intermediate, and preparation methods of the tipracil intermediate, tipracil and tipracil hydrochloride. The preparation method of the tipracil intermediate comprises the following step that 5-chloro-6-methoxycarbonyl uracil is subjected to reductionr eaction to obtain 5-chloro-6-hydroxymethyl uracil; chloro-6-methoxycarbonyl uracil is used for obtaining the 5-chloro-6-methoxycarbonyl uracil through reduction and hydroxyl chloro reaction. The oxidizaiton step in the prior art and a deadly poisonous compound of selenium dioxide are avoided, so that the meidcine qualiyt safety is fundamentally ensured. The reaction conditions of the reductionr eaction are mild; the production cost is reduced. In addition, the yield of final products and middle products in the method is high; the separation purification is easy; the purity is high. The method provided by the invention has the advantages that the raw materials can be easily obtained; the operation is simple; the environment-friendly efefct is good; the process is stable; the method is suitable for industrial production, and the like.

PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES

The present invention relates to substituted pyrimidine derivatives, as well as N- oxides thereof and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener. The invention further relates to intermediates useful in the preparation of such compounds, and to processes for their preparation.

METHOD OF CONTROLLING UNDESIRED VEGETATION

The present invention relates to methods of controlling undesired plant growth in crops of soya through the use of certain substituted pyrimidine derivatives. It also relates to certain novel substituted pyrimidine derivatives. Effective weed control is thereby obtained, whilst at the same time achieving unexpected levels of crop safety.

CHEMICAL COMPOUNDS

The present invention relates to substituted pyrimidine derivatives of as well as N-oxides and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener.

CHEMICAL COMPOUNDS

The present invention relates to substituted pyrimidine derivatives as well as N- oxides and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener.