914486-08-1

Upstream product

• 513-35-9 2-methyl-but-2-ene 
• 146549-21-5 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid 
• 19914-06-8 L-prenylglycine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 16338-48-0 L-allylglycine 

Downstream Products

• 1186094-67-6 Fmoc-Gly-c[Das-Crt-Ser-Asp-Pro-Arg]-Arg-Tyr-Arg-Crt-Arg 
• 1186094-68-7 Fmoc-Gly-Crt-c[Das-Ser-Asp-Pro-Arg-Crt-Arg-Tyr-Arg]-Arg 
• 1186094-60-9 Fmoc-Gly-Agl-Pre-Ser-Asp-Pro-Arg-Agl-Arg-Tyr-Arg-Pre-Arg 
• 1186094-61-0 Fmoc-Gly-Pre-Agl-Ser-Asp-Pro-Arg-Pre-Arg-Tyr-Arg-Agl-Arg 
• 1186094-63-2 Fmoc-Gly-c[Δ4Das-Pre-Ser-Asp-Pro-Arg]-Arg-Tyr-Arg-Pre-Arg 
• 1186094-64-3 Fmoc-Gly-Pre-c[Δ4Das-Ser-Asp-Pro-Arg-Pre-Arg-Tyr-Arg]-Arg 
• 1186094-65-4 Fmoc-Gly-c[Das-Pre-Ser-Asp-Pro-Arg]-Arg-Tyr-Arg-Pre-Arg 
• 1186094-66-5 Fmoc-Gly-Pre-c[Das-Ser-Asp-Pro-Arg-Pre-Arg-Tyr-Arg]-Arg 
• 1186094-69-8 Gly-c[Das-c(Δ4Das-Ser-Asp-Pro-Arg)-Arg-Tyr-Arg]-Arg 

Relevant academic research and scientific papers

Ring closing metathesis of unprotected peptides

An efficient and expedient route to the synthesis of dicarba peptides from protecting group-free sequences is reported using Ru-alkylidene catalysed olefin metathesis. A range of cyclic peptides was prepared from linear peptides containing two Z-crotyl glycine residues. Free amine groups were masked as salts with Br?nsted acids preventing in situ catalyst decomposition. Excellent RCM conversion was obtained in both DMF and methanol.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Compositions and methods for the treatment of bacterial infections include compounds containing dimers of cyclic heptapeptides conjugated to one or more monosaccharide or oligosaccharide moieties. In particular, compounds can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

Methods for the synthesis of dicarba bridges in organic compounds

The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

Bis-dicarba analogues of native dicystine-containing α-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis-hydrogenation strategy.

Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides

According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.