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914638-30-5

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914638-30-5 Usage

Biological Activity

ido-in-1 is an indoleamine-2,3-dioxygenase (ido) inhibitor.ido is expressed in various tissues throughout the body but mainly in cells within the immune system where it is induced in dendritic cells and macrophages at sites of inflammation by cytokines. the overexpression of ido has been implicated in a variety of diseases, such as cancer, neurodegenerative disorders, age-related cataract, and hiv encephalitis.

in vitro

in previous study, ido-in-1 was found to have improved in-vitro human intrinsic clearances without loss in ido cellular potency [1].

in vivo

ido-in-1 analog, named 5l, was chosen for further in vivo studies because of its improved physical chemical properties compared to ido-in-1. the efficacy of 5l was tested in c57bl/6 mice with gmcsf-secreting b16 tumors, where 1-mt had previously shown activity. results showed that the dose-dependent inhibition of tumor growth was linked to increasing exposures of 5l in plasma. in addition, a maximal effect of 50% tumor growth control (tgc) was observed when 5l was subcutaneously administered at 75 mg/kg bid. for comparison, 1-mt showed around 45% tgc when administered as subcutaneous pellets [1].

IC 50

59 nm

references

[1] yue ew, et al. discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. j med chem. 2009 dec 10;52(23):7364-7.

Check Digit Verification of cas no

The CAS Registry Mumber 914638-30-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,6,3 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 914638-30:
(8*9)+(7*1)+(6*4)+(5*6)+(4*3)+(3*8)+(2*3)+(1*0)=175
175 % 10 = 5
So 914638-30-5 is a valid CAS Registry Number.

914638-30-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

1.2 Other means of identification

Product number -
Other names 4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:914638-30-5 SDS

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