914641-11-5Relevant academic research and scientific papers
IMMUNOGENS FOR MENINGITIDIS-A VACCINES
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Page/Page column 31; 49; 50; 51; 52, (2008/06/13)
An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.
Synthesis of stable C-phosphonate analogues of Neisseria meningitidis group A capsular polysaccharide structures using modified Mitsunobu reaction conditions
Teodorovic, Peter,Slaettegard, Rikard,Oscarson, Stefan
, p. 4485 - 4490 (2008/09/19)
Examples of synthetic C-phosphonate analogues of microbial polysaccharide structures containing inter-residue phosphodiester linkages are most rare. The successful construction of such analogues of the Neisseria meningitidis Group A capsular polysaccharid
