914646-71-2

Basic information

• Product Name: (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate
• Synonyms: (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate
• CAS NO: 914646-71-2
• Molecular Weight: 313.148
• Mol File: 914646-71-2.mol

Chemical Properties

• CAS DataBase Reference: (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate(914646-71-2)
• EPA Substance Registry System: (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate(914646-71-2)

Safety Data

• Hazardous Substances Data: 914646-71-2(Hazardous Substances Data)

Upstream product

• 914646-67-6 methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate 
• 914646-69-8 (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-methylbenzoate 
• 18595-12-5 methyl 5-amino-2-methylbenzoate 

Downstream Products

• 914646-90-5 (E)-methyl 3-(2-(3-phenylbenzyl)-1-oxoisoindolin-6-yl)acrylate 
• 914646-78-9 (E)-methyl 3-(2-(3-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylate 
• 951154-49-7 C₁₉H₁₆NO₃I 
• 914647-42-0 (E)-3-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-44-2 (E)-3-(2-(4-phenylbenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-43-1 (E)-3-(2-(3-phenylbenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-27-1 (E)-3-(1-oxo-2-(3-phenylpropyl)isoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-31-7 (E)-3-(2-(3-chlorobenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-30-6 (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-32-8 (E)-3-(2-(4-chlorobenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-38-4 (E)-3-(2-(4-methoxybenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-26-0 (E)-3-(1-oxo-2-phenethylisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide 
• 914647-17-9 (E)-3-(2-(4-phenylbenzyl)-1-oxoisoindolin-6-yl)acrylic acid 
• 914647-16-8 (E)-3-(2-(3-phenylbenzyl)-1-oxoisoindolin-6-yl)acrylic acid 

Relevant articles and documents

Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors

A series of hydroxamic acid derivatives bearing a cyclic amide/imide group as a linker and/or cap structure, prepared during our structural development studies based on thalidomide, showed class-selective potent histone deacetylase (HDAC)-inhibitory activity. Structure-activity relationship studies indicated that the steric character of the substituent introduced at the cyclic amide/imide nitrogen atom, the presence of the amide/imide carbonyl group, the hydroxamic acid structure, the shape of the linking group, and the distance between the zinc-binding hydroxamic acid group and the cap structure are all important for HDAC-inhibitory activity and class selectivity. A representative compound (30w) showed potent p21 promoter activity, comparable with that of trichostatin A (TSA), and its cytostatic activity against cells of the human prostate cell line LNCaP was more potent than that of the well-known HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA).