914654-64-1

Basic information

• Product Name: 3-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)-2-phenylquinoline-4-carboxylic acid
• Synonyms: 3-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)-2-phenylquinoline-4-carboxylic acid
• CAS NO: 914654-64-1
• Molecular Weight: 446.546
• Mol File: 914654-64-1.mol

Chemical Properties

• CAS DataBase Reference: 3-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)-2-phenylquinoline-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)-2-phenylquinoline-4-carboxylic acid(914654-64-1)
• EPA Substance Registry System: 3-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)-2-phenylquinoline-4-carboxylic acid(914654-64-1)

Safety Data

• Hazardous Substances Data: 914654-64-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6457-49-4 4-piperidinemethanol 
• 301232-43-9 tert-butyl 4-(3-oxo-3-phenylpropyl)piperidine-1-carboxylate 
• 91-56-5 indole-2,3-dione 
• 291289-27-5 4-(3-oxo-3-phenyl-propenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 

Downstream Products

• 914654-65-2 3-({1-[(phenylmethoxy)carbonyl]piperidin-4-yl}methyl)-2-phenylquinoline-4-carboxylic acid 
• 914654-67-4 Methyl 2-{[3-({1-[(1,1-Dimethylethoxy)carbonyl]piperidin-4-yl}methyl)-2-phenylquinolin-4-yl]carbonyl}-1-phenylhydrazinecarboxylate 
• 914654-66-3 3-({1-[(1,1-dimethylethoxy)carbonyl]piperidin-4-yl}methyl)-N',2-diphenylquinoline-4-carbohydrazide 
• 914654-70-9 methyl 2-({3-[(piperidin-4-yl)methyl]-2-phenylquinolin-4-yl}carbonyl)-1-phenylhydrazinecarboxylate 

Relevant articles and documents

Quinoline derivatives as neurokinin receptor antagonists

The present invention relates to substituted quinoline hydrazides of Formula (I): wherein R1, R2, R3, R4, R5, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS

The present invention relates to substituted quinoline derivatives of Formula (I); wherein hal, n, A, formula (a) , R1, R2, R3, R4, R5 and R6 are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.

N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II

Introduction of selected amine containing side chains into the 3-position of N′,2-diphenylquinoline-4-carbohydrazide based NK3 antagonists abolishes unwanted hPXR activation. Introduction of a fluorine at the 8-position is necessary to minimize unwanted hIKr affinity and a piperazine N-tert-butyl group is necessary for metabolic stability. The lead compound (8m) occupies receptors within the CNS following oral dosing (Occ90 7 mg/kg po; plasma Occ90 0.4 μM) and has good selectivity and excellent PK properties.