91469-16-8

Basic information

• Product Name: 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE
• Synonyms: 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE
• CAS NO: 91469-16-8
• Molecular Formula: C6H14N4S
• Molecular Weight: 174.27
• Mol File: 91469-16-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 170-171
• Boiling Point: 280.3 °C at 760 mmHg
• Flash Point: 123.3 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.00381mmHg at 25°C
• Refractive Index: 1.624
• PKA: 11.23±0.70(Predicted)
• CAS DataBase Reference: 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE(91469-16-8)
• EPA Substance Registry System: 4-(N-PIPERIDINO)-THIOSEMICARBAZIDE(91469-16-8)

Safety Data

• Hazardous Substances Data: 91469-16-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H14N4S/c7-8-6(11)9-10-4-2-1-3-5-10/h1-5,7H2,(H2,8,9,11)

Upstream product

• 2213-43-6 1-Aminopiperidine 
• 39219-01-7 piperidin-1-yl-dithiocarbamic acid methyl ester 
• 717876-06-7 C₁₁H₁₆N₆OS 

Downstream Products

• 1254359-36-8 5-(4-chlorophenyl)-N-(piperidin-1-yl)-1,3,4-thiadiazol-2-amine 
• 1242266-43-8 5-(4-chloro-phenyl)-4-piperidin-1-yl-2,4-dihydro-[1,2,4]triazole-3-thione 

Relevant articles and documents

Studies on pyrazine derivatives, XLVI: The synthesis of new pyrazine derivatives with N′-(pyrazine-2-carbonyl)-hydrazinecarbodithioic acid methyl ester usage

4-Ω-alkylsubstituted derivatives of 1,2,4-triazole-2-thiones 2-7 were obtained using the high reactivity of N′-(pyrazine-2-carbonyl)- hydrazinecarbodithioic acid methyl ester 1 towards amines. In the reaction with cysteamine 1,3-thiazaethylene-1,2,4-triazole 8 formed. Aromatic amines and N-aminocycloalkylamines gave thiosemicarbazide derivatives 9-12 under the same conditions. The solution of sodium hydroxide caused the decomposition of compounds 11 and 12 and resulted in 4-piperidino- and 4-morpholino- thiosemicarbazides 13 and 14. Compounds 11 and 12 were cyclized to appropriate 4-substituted 1,2,4-triazole-2-thiones 16 and 17 under the influence of DBU or potassium carbonate solution. The heating of derivative 12 with sulfuric acid led to disubstituted 1,3,4-thiadiazole 18. Copyright Taylor & Francis Group, LLC.