91472-94-5

Upstream product

• 50775-37-6 3,3-bis(4-fluorophenyl)propionitrile 
• 50775-33-2 3,3-bis(4-fluorophenyl)-3-hydroxypropanenitrile 
• 50775-35-4 3,3-bis(4-fluorophenyl)-2-propenonitrile 
• 642941-68-2 3-(4-(fluoro)phenyl)acrylamide 
• 1361194-37-7 3,3-bis(4-fluorophenyl)acrylamide 
• 227290-22-4 3,3-bis(4-fluorophenyl)propanamide 
• 345-92-6 4,4'-Difluorobenzophenone 

Downstream Products

• 669-19-2 isonicotinic acid-[3,3-bis-(4-fluoro-phenyl)-propylamide] 
• 114667-48-0 N-[3,3-Bis-(4-fluoro-phenyl)-propyl]-N'-[3-(1H-imidazol-4-yl)-propyl]-guanidine 
• 914386-33-7 isoquinoline-3-carboxylic acid [3,3-bis-(4-fluoro-phenyl)-propyl]-amide 
• 914386-71-3 N-[4,4-bis-(4-fluorophenyl)propyl]-6-hydroxy-nicotinamide 
• 914385-94-7 N-[3,3-bis-(4-fluorophenyl)propyl]-4-methanesulfonylbenzamide 
• 1361005-95-9 N-[3,3-bis-(4-fluoro-phenyl)-propyl]-2-(3-fluoro-4-methansulfonylamino-phenyl)-propionamide 

Relevant academic research and scientific papers

DUAL INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND 5-LIPOXYGENASE

The invention pertains to a novel structure (I) that provides an activity as a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and 5-lipoxygenase (5-LOX). The invention pertains to multiple derivatives of the new class of dual inhibitors, their application in medicine, pharmaceutical compositions comprising them as well as to methods for synthesizing the new compounds.

Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase

Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. Merging of 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase (sEH) pharmacophores led to the discovery of a dual 5-LOX/sEH inhibitor, which was subsequently optimized in terms of potency toward both targets and metabolic stability. The optimized lead structure displayed cellular activity in human polymorphonuclear leukocytes, oral bioavailability, and target engagement in vivo and demonstrated profound anti-inflammatory and anti-fibrotic efficiency in a kidney injury model caused by unilateral ureteral obstruction in mice. These results pave the way for investigating the therapeutic potential of dual 5-LOX/sEH inhibitors in other inflammation- and fibrosis-related disease models.

Silver-Catalyzed Long-Distance Aryl Migration from Carbon Center to Nitrogen Center

Selective cleavage of an inert C-C bond followed by C-O/N bond formation through a long-distance aryl migration from a carbon to a nitrogen center via Ag catalysis is reported. The migration products were easily converted into γ-hydroxy amines and tetrahy

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase

Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties. As part of an effort to identify inhibitors

N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are compounds of the formula (I) with the definitions of A1 D, Q, W, X, Y and Z as indicated in the description, which are active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. (I)