91475-88-6Relevant academic research and scientific papers
STEREOSELECTIVE SYNTHESIS OF SOME CIS 2,3-DISUBSTITUTED CYCLANONES RING SIZE INFLUENCE ON THE STEREOSELECTIVITY OF 2-SUBSTITUTED ENDOCYCLIC ENOLATES PROTONATION
Hatzigrigoriou, E.,Wartski, L.,Seyden-Penne, J.,Toromanoff, E.
, p. 5045 - 5050 (2007/10/02)
Conjugate addition of carbanionic reagents formed from aryl- or phenyl-thioacetonitriles 1a-c and 2 to 2-methyl and 2-phenyl 2-cyclohexenone or 2-methyl 2-cyclopentenone, followed by acidic quench, under kinetic control, leads to different ratios of cis and trans 2,3-disubstituted cyclanones according to ring size.From 2-methyl and 2-phenyl 2-cyclohexenone, the cis isomer is highly predominant (85 to 98percent).From 2-methyl 2-cyclopentanone a cis/trans mixture is obtained: the cis isomer only predominates when a bulky reagent (1c) is used (80percent); in the other cases a mixture of nearly 1:1 is obtained.
CONJUGATE ADDITION REACTION OF TRIMETHYLSILYLACETONITRILE WITH Α,Β-UNSATURATED CARBONYL COMPOUNDS. SYNTHETIC STUDIES TOWARD SESBANIMIDE
Tomioka, Kiyoshi,Koga, Kenji
, p. 1599 - 1600 (2007/10/02)
Lithiated trimethylsilylacetonitrile was allowed to react with some α,β-unsaturated carbonyl compounds to give the corresponding conjugate addition products.
