91485-63-1Relevant academic research and scientific papers
Analgesic activity and metabolism in the mouse of morazone, famprofazone and related pyrazolones
Mrongovius,Neugebauer,Ruker
, p. 161 - 166 (2007/10/02)
The analgesic activity of morazone, famprofazone and some related pyrazolones as compared in mice. The synthesized pyrazolones were up to 5 times more potent than famprofazone. Methamphetamine or phenmetrazine were, with one exception, found in the urine of mice given the pyrazolones. The respective 4-formyl pyrazolones were found as additional urinary metabolites of the morazone analogues (C-4 phenyl ethylamine substituted), whereas the famprofazone analogues (C-3 phenylethylamine-substituted) gave 3-hydroxymethyl pyrazolones as urinary metabolites. Two other metabolites were isolated and identified as metabolites of two of the famprofazone analogues.
