91486-62-3Relevant articles and documents
The Reaction of N-Aminophthalimide With Isothiocyanates
Hearn, Michael J.,Lucas, Laura E.
, p. 615 - 616 (2007/10/02)
N-Aminophthalimide (I) reacted in refluxing isopropyl alcohol with a number of isothiocyanates to give the related 1:1 addition products, N-(3-substituted thioureido)phthalimides III.On the other hand, heating I directly with an excess of neat arylisothiocyanates produced the N-arylphthalimides IV.As shown for IIIa, the 1:1 addition products are conveniently deblocked by the Ing-Manske procedure to yield the 4-substituted thiosemicarbazide.