914917-91-2

Upstream product

• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 121845-40-7 ethyl 5-amino-1-ethyl-1H-imidazole-4-carboxylate 

Downstream Products

• 852854-33-2 2-chloro-1-(4-chlorophenyl)-9-ethyl-1,9-dihydro-6H-purin-6-one 

Relevant academic research and scientific papers

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I) which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VRl, also known as TRPVl).

2,3-SUBSTITUTED FUSED PYRIMIDIN-4(3H)-ONES AS VR1 ANTAGONISTS

A compound of formula (I), wherein W is formula (1); A is a benzene ring, a fêve-membered heteroaromatic ring containing 1, 2 or 3 heteroatoms independently chosen from O, N and S, providing that no more than one O or S atom is present, or a six- membered

2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).