914944-23-3

Basic information

• Product Name: methyl 3-fluoro-5-(2-trimethylsilylethynyl)benzoate
• Synonyms: methyl 3-fluoro-5-(2-trimethylsilylethynyl)benzoate
• CAS NO: 914944-23-3
• Molecular Weight: 250.345
• Mol File: 914944-23-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 3-fluoro-5-(2-trimethylsilylethynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-fluoro-5-(2-trimethylsilylethynyl)benzoate(914944-23-3)
• EPA Substance Registry System: methyl 3-fluoro-5-(2-trimethylsilylethynyl)benzoate(914944-23-3)

Safety Data

• Hazardous Substances Data: 914944-23-3(Hazardous Substances Data)

Upstream product

• 176548-70-2 3-bromo-5-fluorobenzoic acid 
• 334792-52-8 methyl 3-bromo-5-fluoro-benzoate 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 914944-27-7 3-[1,6-dihydro-1-methyl-4-((methyl)tert-butoxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]-5-fluoro-benzoic acid methyl ester 
• 914944-30-2 3-[1,6-dihydro-1-methyl-4-((methyl)tert-butoxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]-5-fluoro-benzoic acid 
• 914944-25-5 3-((6-amino-4-(tert-butyloxycarbonyl(methyl)amino)-1-methyl-1H-imidazo[4,5-c]pyridine-7-yl)ethynyl)-5-fluorobenzoic acid methyl ester 
• 914944-26-6 3-((4-tert-butyloxycarbonyl(methyl)amino)-1-methyl-6-(2,2,2-trifluoroacetamido)-1H-imidazo[4,5-c]pyridin-7-yl)ethynyl-5-fluorobenzoic acid methyl ester 
• 914944-24-4 methyl 3-ethynyl-5-fluorobenzoate 

Relevant articles and documents

ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA

The present disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 means a fluorine atom or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms; R2 means a chlorine atom, a linear alkyl radical containing 1, 2 or 3 carbon atoms or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms, and R means a hydrogen atom or a radical of formula (la). The present disclosure also relates to processes for their preparation as well their therapeutic uses, in particular such as for use in the treatment of malaria.