91498-90-7

Upstream product

• 51985-54-7 2,5-dichloro-benzenesulfonic acid-anhydride 
• 62-53-3 aniline 
• 106-46-7 para-dichlorobenzene 
• 5402-73-3 2,5-dichlorobenzenesulphonyl chloride 

Downstream Products

• 93345-02-9 C₁₉H₁₄Cl₂N₄O₆S₂ 
• 93345-04-1 C₁₈H₂₃Cl₂N₂O₇PS₂ 
• 93345-05-2 N-[4-(3-Aza-tricyclo[3.2.1.0^2,4]octane-3-sulfonyl)-phenyl]-2,5-dichloro-benzenesulfonamide 
• 93345-01-8 C₁₉H₁₅Cl₂N₃O₄S₂ 
• 93345-06-3 2,5-Dichloro-N-[4-(3,5-dimethyl-pyrazole-1-sulfonyl)-phenyl]-benzenesulfonamide 
• 93345-00-7 C₁₅H₁₅Cl₂N₃O₄S₂ 
• 93345-03-0 4-(2,5-Dichloro-benzenesulfonylamino)-benzenesulfonyl azide 
• 93344-99-1 C₁₂H₁₁Cl₂N₃O₄S₂ 
• 93344-98-0 2,5-Dichloro-N-(4-dimethylsulfamoyl-phenyl)-benzenesulfonamide 
• 93344-97-9 2,5-dichlorobenzenesulfonyl sulfanilyl chloride 

Relevant academic research and scientific papers

Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein

Influenza viruses cause approximately half a million deaths every year worldwide. Vaccines are available but partially effective, and the number of antiviral medications is limited. Thus, it is crucial to develop therapeutic strategies to counteract this major pathogen. Influenza viruses enter the host cell via their hemagglutinin (HA) proteins. The HA subtypes of influenza A virus are phylogenetically classified into groups 1 and 2. Here, we identified an inhibitor of the HA protein, a tertiary aryl sulfonamide, that prevents influenza virus entry and replication. This compound shows potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1 and 2. Synthesis of derivatives of this aryl sulfonamide identified moieties important for antiviral activity. This compound may be considered as a lead for drug development with the intent to be used alone or in combination with other influenza A virus antivirals to enhance pan-subtype efficacy.

Syntheses of N4-(Alkyl or arylsulfonyl)sulfanilyl Derivatives

2,4-Dichloro, 2,5-dichloro and 3,4-dichloro-benzene-sulfanilides react with chlorosulfonic acid at low temperature to give good yields of the corresponding dichlorobenzenesulfonyl sulfanilyl chlorides.A number of chlorides have been converted into derivatives by reaction with nucleophiles, such as dimethylamine, hydrazine and sodium azide.N4-Acetamidobenzenesulfonylsulfanilyl derivatives have been prepared by the condensation of N4-acetylsulfanilyl chloride with the appropriate sulfanilyl derivative.Methylsulfonanilide reacts with chlorosulfonic acid to give N4-(methylsulfonyl)sulfanilyl chloride.The compounds have been tested for their antibacterial and antifungal activity.