915038-24-3

Basic information

• Product Name: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-
• Synonyms: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-;(3alpha,5beta)-6-Ethylidene-3-hydroxy-7-oxocholan-24-oic acid;(4R)-4-((3R,5R,10R,13R)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadeca hydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;Obeticholic acid inpurities;Cholan-24-oic acid, 6-ethylidene-3-hydroxy-7-oxo-, (3α,5β)-
• CAS NO: 915038-24-3
• Molecular Formula: C₂₆H₄₀O₄
• Molecular Weight: 416.5934
• EINECS: -0
• Mol File: 915038-24-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 573.1±43.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-(915038-24-3)
• EPA Substance Registry System: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-(915038-24-3)

Safety Data

• Hazardous Substances Data: 915038-24-3(Hazardous Substances Data)

Usage

Uses

(3α,?5β)?-6-Eethylidene-?3-?hydroxy-?7-?oxocholan-?24-?oic Acid is an impurity of obeticholic acid.

Upstream product

• 2862-62-6 3α-ol-6-oxo-5β-24-cholanoic acid methyl ester 
• 2868-48-6 methyl hyodeoxycholate 
• 83-49-8 Hyodeoxycholic Acid 
• 21066-15-9 methyl 3α-acetoxy-6-oxo-5β-cholanoate 
• 863239-58-1 3α,7α-bis((trimethylsilyl)oxy)-6-ene-5β-cholanic acid methyl ester 
• 83-46-5 β-sitosterol 
• 10538-59-7 7-ketolithocholic methyl ester 
• 75-07-0 acetaldehyde 
• 474-25-9 chenodeoxycholic acid 
• 859-97-2 3,7-diketocholanic acid 
• 122960-85-4 3α-tetrahydropyranyloxy-7-keto-5β-cholan-24-oic acid 

Downstream Products

• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 
• 1537866-42-4 6α-ethyl-3α-formyloxy-7-keto-5β-cholan-24-oic acid 
• 865244-30-0 (3α,5β,6α,7β)-6-ethyl-3,7-dihydroxycholan-24-oic acid 

Relevant articles and documents

Preparation method of obeticholic acid

The invention relates to a preparation method of obeticholic acid, in particular to a compound shown as a formula III which is described in the specification, a preparation method of the compound anda method for preparing obeticholic acid through the compound III. The method has the advantages of mild reaction conditions, few byproducts, simplicity and convenience in operation, high total yield and the like, and is suitable for large-scale production.

Compound for treating metabolic diseases as well as preparation method and application thereof

The invention provides a compound for treating metabolic diseases, the compound has a structure represented by formula (I) or formula (II), or a racemate, a stereoisomer, a geometric isomer, a tautomer, a solvate, a hydrate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The compounds provided by the invention are FXR and/or TGR5 receptor activators, and the compounds havethe activity of activating FXR and/or TGR5 receptors, and can be used for preparing medicines for treating chronic liver diseases, metabolic diseases or portal hypertension.

Preparation method of obeticholic acid and intermediate thereof

The invention discloses a preparation method of obeticholic acid and an intermediate thereof. The invention provides a preparation method of a compound V. The preparation method of the compound V comprises the following steps: carrying out hydroxyl protective reaction on a compound VI and a hydroxyl protective reagent to obtain the compound V. The preparation method is simple and convenient to operate, low in cost, gentle in condition, environmentally friendly and suitable for industrialization.