91506-70-6Relevant academic research and scientific papers
Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor
Song, Eun Young,Kaur, Navneet,Park, Mi-Young,Jin, Yinglan,Lee, Kyeong,Kim, Guncheol,Lee, Ki Youn,Yang, Jee Sun,Shin, Jae Hong,Nam, Ky-Youb,No, Kyoung Tai,Han, Gyoonhee
, p. 1519 - 1524 (2008/09/21)
A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.
Synthesis, Photolysis and Pyrolysis of 1-(2'-Benzothiazolyl)-5-aryltetrazoles
Kamala, K.,Rao, P. Jayaprasad,Reddy, K. Kondal
, p. 1194 - 1196 (2007/10/02)
Aroylaminobenzothiazoles (II), have been converted into 1-(2'-benzothiazolyl)-5-aryltetrazoles (IV) by treatment with PCl5 followed by azidolysis with sodium azide in aequeous acetone solution.Pyrolysis of IV in tetralin affords exclusively 2-aryl-s-triaz
