91506-72-8Relevant academic research and scientific papers
Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes
Premaletha, Sethulekshmy,Ghosh, Arghya,Joseph, Sumi,Yetra, Santhivardhana Reddy,Biju, Akkattu T.
, p. 1478 - 1481 (2017)
A mild, general, and high yielding synthesis of N-acyl 2-aminobenzothiazoles has been demonstrated by N-heterocyclic carbene (NHC)-organocatalyzed direct amidation of aldehydes with 2-aminobenzothiazoles proceeding via acyl azolium intermediates. The carbene generated from the triazolium salt under oxidative conditions was the key for the success of this reaction. The method was subsequently applied to the synthesis of various biologically important N-acyl 2-aminobenzothiazoles.
METHODS AND COMPOSITIONS FOR SELECTIVE AND TARGETED CANCER THERAPY
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Page/Page column 183, (2015/03/28)
Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.
