915087-27-3

Basic information

• Product Name: N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide
• Synonyms: N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide;RD 162
• CAS NO: 915087-27-3
• Molecular Formula: C22H16F4N4O2S
• Molecular Weight: 476.4466528
• Mol File: 915087-27-3.mol

Chemical Properties

• Appearance: /
• Density: 1.55
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide(915087-27-3)
• EPA Substance Registry System: N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide(915087-27-3)

Safety Data

• Hazardous Substances Data: 915087-27-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide is used as a pharmaceutical compound for the development of new drugs. Its unique molecular structure allows it to target specific biological pathways and receptors, making it a promising candidate for the treatment of various diseases.
Used in Chemical Research:
In the field of chemical research, N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide serves as a valuable research tool. Its complex structure provides insights into the synthesis and properties of similar compounds, contributing to the advancement of organic chemistry.
Used in Material Science:
N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide is used in material science for the development of new materials with unique properties. Its molecular structure can be tailored to create materials with specific characteristics, such as improved stability, reactivity, or selectivity.
Used in Environmental Applications:
In environmental applications, N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide can be employed as a component in the development of eco-friendly products. Its unique chemical properties may contribute to the creation of materials that are biodegradable or have reduced environmental impact.
Used in Analytical Chemistry:
N-Methyl-4-[7-(4-cyano-3-trifluoromethylphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide is used in analytical chemistry as a reference compound or as a component in the development of new analytical methods. Its unique structure and properties can be utilized to improve the sensitivity, selectivity, or accuracy of analytical techniques.

Biological Activity

rd162 is an androgen receptor (ar) antagonist.metastatic prostate cancer is treated with drugs antagonizinf androgen action, but most patients progress to a more aggressive form of the disease named castration-resistant prostate cancer, driven by elevated expression of the androgen receptor (ar).

in vitro

rd162 was optimized from a screen for nonsteroidal antiandrogens retaining activity in the setting of increased androgen receptor expression. rd162 could bind to the androgen receptor with greater relative affinity than the clinically used bicalutamide, reduce the efficiency of the nuclear translocation, and impair both dna binding to androgen response elements and recruitment of coactivators [1].

in vivo

previous evidence suggested that the activity of rd162 in these mice was mediated through ar inhibition. the antitumor activity in the lncap/ar model was dose-dependent, with some slowing of tumor growth at 0.1 mg/kg rd162 and a few tumor regressions at 1 mg/kg, correlating closely with the effect of these same doses on ar transcriptional activity in the luciferase imaging experiment. in addition, neither bicalutamide nor rd162 impaired the growth of ar-negative du145 prostate cancer xenografts [1].

IC 50

30.9 nm

references

[1] c. tran, s. ouk, n. j. clegg, et al. development of a second-generation antiandrogen for treatment of advanced prostate cancer. science 324(5928), 787-790(2009).

Upstream product

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Relevant articles and documents

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