915091-08-6

Upstream product

• 618888-60-1 methyl (1S,3R,4R,5S)-5-allyl-1,3,4-trihydroxycyclohexane-1-carboxylate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 915090-88-9 (1S,3S,4R,5R)-1-Acetoxy-3-(2-acetoxy-ethyl)-5-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-4-hydroxy-cyclohexanecarboxylic acid methyl ester 
• 915090-85-6 (1S,3S,5R)-1-Acetoxy-3-(2-acetoxy-ethyl)-5-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-4-oxo-cyclohexanecarboxylic acid methyl ester 
• 915091-06-4 (2S,3S,4aR,6S,8S,8aR)-6-Hydroxy-8-(2-hydroxy-ethyl)-2,3-dimethoxy-2,3-dimethyl-octahydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester 
• 915090-86-7 (2S,3S,4aR,6S,8S,8aR)-8-Allyl-6-hydroxy-2,3-dimethoxy-2,3-dimethyl-octahydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester 
• 915090-87-8 (1S,3S,4R,5R)-1-Acetoxy-3-(2-acetoxy-ethyl)-4,5-dihydroxy-cyclohexanecarboxylic acid methyl ester 
• 1054771-90-2 (3S,4aS,5S,7S,8aR)-7-Acetoxy-5-(2-acetoxy-ethyl)-3-benzyl-4a-cyano-2-oxo-octahydro-benzo[1,4]oxazine-7-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of (-)-5,6,11-trideoxytetrodotoxin and its 4-epimer

(Chemical Equation Presented) The first total synthesis of 5,6,11-trideoxytetrodotoxin (1) and its 4-epimer were achieved. The synthesis is characterized by the stereoselective construction of the quaternary amino carbon center at C8a by an asymmetric tra