915097-14-2Relevant academic research and scientific papers
The design and synthesis of inhibitors of pantothenate synthetase
Tuck, Kellie L.,Saldanha, S. Adrian,Birch, Louise M.,Smith, Alison G.,Abell, Chris
, p. 3598 - 3610 (2006)
Pantothenate synthetase catalyses the ATP-dependent condensation of d-pantoate and β-alanine to form pantothenate. Ten analogues of the reaction intermediate pantoyl adenylate, in which the phosphodiester is replaced by either an ester or sulfamoyl group, were designed as potential inhibitors of the enzyme. The esters were all modest competitive inhibitors, the sulfamoyls were more potent, consistent with their closer structural similarity to the pantoyl adenylate intermediate. The Royal Society of Chemistry 2006.
