915100-66-2

Basic information

• Product Name: (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene
• Synonyms: (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene
• CAS NO: 915100-66-2
• Molecular Weight: 203.12
• Mol File: 915100-66-2.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene(915100-66-2)
• EPA Substance Registry System: (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene(915100-66-2)

Safety Data

• Hazardous Substances Data: 915100-66-2(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 956924-25-7 2-nitro-1-(2,4,5-trifluorophenyl)ethanol 

Downstream Products

• 915100-67-3 1-benzyl-3-nitro-4-(2,4,5-trifluorophenyl)pyrrolidine 
• 927206-50-6 1,2,4-trifluoro-5-(1-nitropent-4-en-2-yl)benzene 
• 1286756-57-7 (4R,5R)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate 
• 1286756-58-8 (4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate 
• 1286756-59-9 (1R,2S)-2',4',5'-trifluoro-2-nitro-1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid 
• 1286756-60-2 ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone 
• 913623-70-8 C₂HF₃O₂*C₁₉H₁₇F₆N₅O 
• 1286756-56-6 (R)-4-nitro-3-(2,4,5-trifluorophenyl)butanal 
• 1384175-50-1 8-nitro-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carbonitrile 
• 1384175-49-8 8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carbonitrile 
• 1384175-52-3 (R)-N-((7R,8S)-3-cyano-7-(2,4.5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)-2-hydroxy-2-phenylacetamide 
• 1384175-56-7 (7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 1384175-66-9 8-nitro-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 1384175-67-0 8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 

Relevant articles and documents

Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes

Poor medication adherence is one of the leading causes of suboptimal glycaemic control in approximately half of the patients with type 2 diabetes mellitus (T2DM). Long-acting antidiabetic drugs are clinically needed for improving patients' compliance. Dipeptidyl peptidase-4 (DPP-4) inhibitors play an increasingly important role in the treatment of T2DM because of their favorable properties of weight neutrality and hypoglycemia avoidance. Herein, we report the successful discovery and scale-up synthesis of compound 5, a structurally novel, potent, and long-acting DPP-4 inhibitor for the once-weekly treatment of T2DM. Inhibitor 5 has fast-associating and slow-dissociating binding kinetics profiles as well as slow clearance rate and long terminal half-life pharmacokinetic properties. A single-dose oral administration of 5 (3 mg/kg) inhibited >80% of DPP-4 activity for more than 7 days in diabetic mice. The long-term antidiabetic efficacies of 5 (10 mg/kg, qw) were better than those of the once-weekly trelagliptin and omarigliptin, especially in decreasing the hemoglobin A1c level.

Preparation method of 2,3-dihydro-1H-benzo[f] chromane-2-amine derivative

The invention provides a preparation method of a (2S, 3R)-2-amidogen-3-(2,4,5-trifluorophenyl)-9-methoxyl-2,3-dihydro-1H-benzo[f] chromane-8 bit substitutive derivative shown as a formula I shown in the accompanying drawing, wherein R is selected from H, OCH3, CN, SO2CH3 and NHSO2CH3. The method has the advantages that the yield is high; the purification is convenient; the cost is low, and the like.

Benzo-hexatomic ring derivative used as DPP-4 inhibitor and application of benzo-hexatomic ring derivative

The invention relates to a benzo-hexatomic ring derivative used as a DPP-4 inhibitor and application of the benzo-hexatomic ring derivative, in particular to compounds shown as in formula I, medicine compositions with the compounds shown as in the formula I and application of the compounds in preparing medicines for treating diseases related to DPP-4 or inhibiting the DPP-4.