915134-70-2

Upstream product

• 345-90-4 bis(4-fluorophenyl)methylbromide 
• 27064-94-4 4,4'-difluorobenzhydryl chloride 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 

Downstream Products

• 924268-74-6 D-2-acetylamino-3,3-bis(4-fluorophenyl)propanoic acid (-)-cinchonidine salt 
• 915134-71-3 L-2-amino-3,3-bis(4-fluorophenyl)propanoic acid hydrochloride 

Relevant academic research and scientific papers

Production method of optically active dephenylalanine compounds

Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3): wherein each symbol is as defined in the specification.

Production method of optically active diphenylalanine compounds

The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected