915234-76-3

Upstream product

• 1032734-16-9 (2R,3S,4S,5S,6E,8S,9Z)-4-hydroxymethyl-1-(p-methoxybenzyloxy)-2,6,8-trimethylundeca-6,9-diene-3,5-diol 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 346708-33-6 (2R,3S,4S,5S,6E,8S,9Z)-4-(tert-butyldimethylsilyloxymethyl)-1-(p-methoxybenzyloxy)-2,6,8-trimethylundeca-6,9-diene-3,5-diol 
• 915234-74-1 (2R,4R,5S,6E,8S,9Z)-4-(tert-butyldimethylsilyloxymethyl)-5-hydroxy-1-(p-methoxybenzyloxy)-2,6,8-trimethylundeca-6,9-diene-3-one 

Downstream Products

• 1032734-17-0 (2R,3S,4S,5S,6E,8S,9Z)-5-(tert-butyldimethylsilyloxy)-1-(p-methoxybenzyloxy)-4-[(p-methoxyphenyl)diphenylmethoxymethyl]-2,6,8-trimethylundeca-6,9-diene-3-ol 
• 1026199-24-5 (2S,3R,4S,5S,6E,8S,9Z)-5-(tert-butyldimethylsilyloxy)-3-(p-methoxybenzyloxy)-4-[(p-methoxyphenyl)diphenylmethoxymethyl]-2,6,8-trimethylundeca-6,9-diene-1-al 
• 1032734-18-1 (2S,3S,4E,4'S,5'R,6S,7Z)-3-(tert-butyldimethylsilyloxy)-1-[(p-methoxyphenyl)-diphenylmethoxy]-2-[2'-(p-methoxyphenyl)-5'-methyl-[1,3]dioxan-4'-yl]-4,6-dimethylnona-4,7-diene 
• 1032734-19-2 (2R,3S,4S,5S,6E,8S,9Z)-5-(tert-butyldimethylsilyloxy)-3-(p-methoxybenzyloxy)-4-[(p-methoxyphenyl)diphenylmethoxymethyl]-2,6,8-trimethylundeca-6,9-diene-1-ol 

Relevant academic research and scientific papers

The total synthesis of (+)-tedanolide - A macrocyclic polyketide from marine sponge tedania ignis

Tedanolide, which was isolated by Schmitz in 1984 from the marine sponge Tedania ignis, is a highly cytotoxic macrolide leading to strong growth inhibition of P338 tumor cells in bioassays. A unique structural feature of the known tedanolides is the prima

The total synthesis of (+)-tedanolide

The first total synthesis of the (+)-tedanolide is described. Pivotal steps are the Felkin-selective aldol coupling between C12 and C13 and an efficient Mitsunobu macrolactonization. Selective protecting group transformations and subsequent oxidations gen