91527-72-9Relevant academic research and scientific papers
A new efficient domino approach for the synthesis of coumarin-pyrazolines as antimicrobial agents targeting bacterial d-alanine-d-alanine ligase
Chate, Asha V.,Redlawar, Ankita A.,Bondle, Giribala M.,Sarkate, Aniket P.,Tiwari, Shailee V.,Lokwani, Deepak K.
supporting information, p. 9002 - 9011 (2019/06/17)
The inhibition of d-alanine-d-alanine ligase (Ddl) prevents bacterial growth, which makes this enzyme an attractive and viable target in the urgent search for novel effective antimicrobial drugs. In this work, a series of novel coumarin-linked pyrazoline
Bismuth triflate: A highly efficient catalyst for the synthesis of bio-active coumarin compounds via one-pot multi-component reaction
El-Remaily, Mahmoud. Abd El Aleem. Ali. Ali.
, p. 1124 - 1130 (2015/07/07)
A series of coumarin-chalcone hybrid compounds and coumarins linked to pyrazoline was synthesized in good yield and short time using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester and an aromatic aldehyde (in the case of the coumarin-chalcone derivatives) in addition to hydrazine hydrate (in the case of the pyrazolyl coumarins) in the presence of a catalytic amount of bismuth triflate [Bi(OTf)3, 5 mol%]. The synthesized compounds showed scavenging activity towards the free radical 2,2-diphenyl-1-picrylhydrazyl. All compounds were characterized using IR, 1H NMR and 13C NMR spectroscopy.
Synthesis and characterization of some heteroaromatic derivatives of 3-but-2-enoyl-chromen-2-one and their potential as anti-inflammatory agents
Dixit, Priyanka,Tripathi, Avinash C.,Saraf, Shailendra K.
, p. 1431 - 1436 (2014/01/06)
A novel series of chromen-2-ones containing pyrazole, isoxazole, oxazine, and thiazine substitutions have been synthesized by reacting 3-[3-(4-chloro-phenyl)-acryloyl]-chromen-2-one and 3-[3-(3-methoxy-phenyl)- acryloyl]-chromen-2-one with various cyclizing agents such as hydrazine, phenylhydrazine, urea, and thiourea. The structures of all the synthesized compounds were confirmed by the use of IR, 1H-NMR, mass spectroscopy, and elemental analysis data. All the newly synthesized compounds were evaluated for their anti-inflammatory activity at a dose of 100 mg/kg body weight in carrageenan-induced rat paw edema model. The entire series of the compounds exhibited moderate to good anti-inflammatory activity, with the percentage inhibition of edema formation ranging from 39.99 to 63.15 against the reference drug ibuprofen (100 mg/kg) that showed 78.96% inhibition at the third hour. Compounds 3a, 3c, and 3d showed good inhibitory activity, whereas compounds 3b, 3e, 3f, and 3j showed moderate inhibitory activity at the third hour.
