91527-77-4

Upstream product

• 3949-36-8 3-acetylcoumarin 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 90-02-8 salicylaldehyde 

Downstream Products

• 329740-87-6 3-[5-[4-(dimethylamino)phenyl]-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]coumarin 

Relevant academic research and scientific papers

The effects of bromine atoms on the photophysical and photochemical properties of 3-cinnamoylcoumarin derivatives

Eight coumarin derivatives (T1-T8) with or without modification using one or two bromine atoms were synthesized through the aldol condensation reaction. Their photophysical, photochemical and electrochemical properties were investigated. It was shown that

Hybrid Pharmacophoric Approach in the Design and Synthesis of Coumarin Linked Pyrazolinyl as Urease Inhibitors, Kinetic Mechanism and Molecular Docking

The current research article reports the synthesis of coumarinyl pyrazolinyl thioamide derivatives and their biological activity as inhibitors of jack bean urease. The coumarinyl pyrazolinyl thioamides were synthesized by reacting thiosemicarbazide with n

Synthesis and florescent properties of 5-aryl-3-(3-coumarinyl)-1-benzothiazolyl-2-pyrazolines

A series of novel 5-Aryl-3-(3-coumarinyl)-1-benzothiazolyl-2-pyrazolines have been synthesized by the reaction of 3-coumarinyl chalcones with 2-hydrazinobenzothiazole in hot ethanol. And the structures of these new compounds have been characterized by 1HNMR, MS and elemental analysis. The fluorescence spectra of these compounds were also measured. All the compounds showed up strong green light emissions (λem: 557-570nm). The results showed that the absorption maxima of the compound vary from 415 to 420nm depending on the group bonded to pyrazolines rings.

Bismuth triflate: A highly efficient catalyst for the synthesis of bio-active coumarin compounds via one-pot multi-component reaction

A series of coumarin-chalcone hybrid compounds and coumarins linked to pyrazoline was synthesized in good yield and short time using a simple and efficient method. This method involved the one-pot reaction of salicylaldehyde, an α-ketoester and an aromatic aldehyde (in the case of the coumarin-chalcone derivatives) in addition to hydrazine hydrate (in the case of the pyrazolyl coumarins) in the presence of a catalytic amount of bismuth triflate [Bi(OTf)3, 5 mol%]. The synthesized compounds showed scavenging activity towards the free radical 2,2-diphenyl-1-picrylhydrazyl. All compounds were characterized using IR, 1H NMR and 13C NMR spectroscopy.

Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect

Twenty one pyrazoline containing benzenesulfonylureas were synthesized and docked against PPAR-γ target. All the compounds were first screened for their antidiabetic potential by oral glucose tolerance test and then six active compounds were assessed on S

Synthesis and biological evaluation of a novel series of 1,3-dicoumarinyl-5-aryl-2-pyrazolines

In the present paper novel 1,3,5-trisubstituted 2-pyrazolines (4a-q) were synthesized via condensation of different substituted 3-cinnamoyl-2-oxo-2H- chromenes (2a-q) with 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazide (3). Chalcones were prepared vi

Microwave-assisted synthesis and evaluation of antimicrobial activity of 3-{3-(s-aryl and s-heteroaromatic)acryloyl}-2H-chromen-2-one derivatives

(Chemical Equation Presented) The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the

Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

A novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines (3a-l) were synthesized by reacting various substituted 3-aryl-1-(3-coumarinyl)propan-1-ones (2a-l) with phenylhydrazine in the presence of hot pyridine. Structures of all new s

A facile one pot synthesis of 2-aryl-4-[2H-2-oxo-[1]benzopyran-3-yl] 2,3-dihydro and 2,5-dihydro-1,5-benzothiazepines

3-acetyl coumarins on condensation with various aromatic aldehydes in the presence of piperidine gave corresponding chalcones in a solid state under solvent free conditions. These chalcones are isolated and characterized. The insitu-formed chalcones (1) a

Synthesis of some new 3-cummamoyl counarin oximes and related cyclisation products derived from 3-acetyl coumarin

3-Acetylcoumarin 1 reacts with aldehydes to form corresponding 3-cummamoyl counarin 2a-g. Oximation of 2a-g with hydroxylamine hydrochloride in ethanol and (or) isopropanol aqueous solution give new 3-[1-oxo-3-(substituted-phenyl)]-2- propenyl-2H-1-benzop