915276-62-9Relevant academic research and scientific papers
Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor
Burch, Jason D.,Belley, Michel,Fortin, Rejean,Deschenes, Denis,Girard, Mario,Colucci, John,Farand, Julie,Therien, Alex G.,Mathieu, Marie-Claude,Denis, Danielle,Vigneault, Erika,Levesque, Jean-Francois,Gagne, Sebastien,Wrona, Mark,Xu, Daigen,Clark, Patsy,Rowland, Steve,Han, Yongxin
, p. 2048 - 2054 (2008/12/20)
A new series of EP4 antagonists based on a quinoline acylsulfonamide scaffold have been identified as part of our on-going efforts to develop treatments for chronic inflammation. These compounds show subnanomolar intrinsic binding potency towar
