915296-79-6

Basic information

• Product Name: Butanoic acid, 4-chloro-2-[(2,4-dichlorophenyl)methylene]-3-oxo-, ethyl ester, (2Z)-
• CAS NO: 915296-79-6
• Molecular Formula: C13H11Cl3O3
• Molecular Weight: 321.588
• Mol File: 915296-79-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-chloro-2-[(2,4-dichlorophenyl)methylene]-3-oxo-, ethyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-chloro-2-[(2,4-dichlorophenyl)methylene]-3-oxo-, ethyl ester, (2Z)-(915296-79-6)
• EPA Substance Registry System: Butanoic acid, 4-chloro-2-[(2,4-dichlorophenyl)methylene]-3-oxo-, ethyl ester, (2Z)-(915296-79-6)

Safety Data

• Hazardous Substances Data: 915296-79-6(Hazardous Substances Data)

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 915296-80-9 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 915296-83-2 4-(2,4-dichlorophenyl)-3-(hydroxymethyl)-6-(4-methoxyphenyl)-2-methyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one 
• 1057292-60-0 4-(2,4-Dichlorophenyl)-6-(4-methoxyphenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid 
• 915731-62-3 (R)-tert-Butyl 2-(3-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate 
• 915296-81-0 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate 

Relevant articles and documents

Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b] pyridin-6(7H)-yl)-N, N-dimethylacetamide (BMS-767778)

Optimization of a 5-oxopyrrolopyridine series based upon structure-activity relationships (SARs) developed from our previous efforts on a number of related bicyclic series yielded compound 2s (BMS-767778) with an overall activity, selectivity, efficacy, PK, and developability profile suitable for progression into the clinic. SAR in the series and characterization of 2s are described.

Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods

Compounds are provided having the formula (I) wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases.