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• 20116-64-7 phthalazin-1,4-dione 
• 85-44-9 phthalic anhydride 

Relevant academic research and scientific papers

Green procedure for the synthesis of phthalazino[2,3-b]phthalazine-5,7,12, 14-tetraones

Different novel phthalazino[2,3-b]phthalazine-5,7,12,14-tetraones were synthesized in a simple and environmentally benign method from the reaction of phthalic anhydrides with semicarbazide or thiosemicarbazide using montmorillonite K-10 clay as solid heterogeneous acidic catalyst and microwaves under solvent-free conditions in good yields and short reaction times. Products were characterized by the elemental analysis, IR, NMR, and mass spectrometry. Copyright Taylor & Francis Group, LLC.

Montmorillonite K-10 clay as reusable heterogeneous catalyst for the microwave-mediated solventless synthesis of phthalazinetetraones

Different phthalazino[2,3-b]phthalazine-5,7,12,14-tetraones were synthesized in a simple and environmentally benign method from the reaction of some phthalic anhydrides with semicarbazide or thiosemicarbazide using montmorillonite K-10 clay as solid heterogeneous acidic catalyst and microwaves under solvent-free conditions in good yields and short reaction times. The present method has many obvious advantages compared with those reported in the literature, including high efficiency, higher yield, operational simplicity, environmental benignity, and the possibility of recycling the solid clay. The solid clay catalyst used in the first cycle of the reactions was successfully recovered and reused in the second cycle, showing a gradual decrease in activity.

Synthesis and Biological Activity Evaluation of Differently Substituted 1,4-Dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides and -carbothioamides

Differently substituted phthalic anhydrides can react either with semicarbazide or thiosemicarbazide to give respectively 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides or 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carbothioamides under mild conditions and generally with good yields. These compounds have been tested in order to evaluate their anti-microbial activity. Furthermore a new synthetic pathway to phtha-lazino[2,3-b]phthalazine-5,7,12,14-tetraone has been devised.

Mechanistic Aspects of Diazaquinone Chemiluminescence

Twelve cyclic hydrazides of aromatic and heterocyclic o-dicarboxylic acids were converted into diazaquinones by treatment with t-butyl hypochlorite.Chemiluminescence was produced from all diazaquinones on treatment with HO2- derived from hydrogen peroxide and potassium hydroxide.Diazaquinones derived from pyridine and pyrazine o-dicarboxylic acid hydrazides afforded chemiluminescence with hydrogen peroxide alone.Such nitrogen bases and N-oxides increase the nucleophilicity of hydrogen peroxide by complex formation and this effect was also exemplified by observation of chemiluminescence from phthalazine-1,4-diones, hydrogen peroxide and either pyridine or pyridine N-oxide.Highly reactive diazaquinones emit light with aqueous alkali and oxygen.No chemiluminescence was produced with organic bases and oxygen which suggests the involvement of a different mechanism compared with the hydroperoxide anion case.