915363-56-3

Basic information

• Product Name: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
• Synonyms: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile;8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl]amino]quinoline-3-carbonitrile;Cot inhibitor-2;3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]Methyl]aMino]-
• CAS NO: 915363-56-3
• Molecular Formula: C₂₆H₂₅Cl₂FN₈
• Molecular Weight: 539.443
• Mol File: 915363-56-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 713.3 °C at 760 mmHg
• Flash Point: 385.2 °C
• Appearance: /
• Density: 1.45
• Vapor Pressure: 3.41E-20mmHg at 25°C
• Refractive Index: 1.702
• PKA: 8.62±0.10(Predicted)
• CAS DataBase Reference: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile(915363-56-3)
• EPA Substance Registry System: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile(915363-56-3)

Safety Data

• Hazardous Substances Data: 915363-56-3(Hazardous Substances Data)

Usage

General Description

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile is a chemical compound with a complex structure, consisting of a quinoline ring with various substituents. It contains chlorine, fluorine, nitrogen, carbon, and hydrogen atoms in its structure. 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile may have potential applications in the pharmaceutical industry, due to its structural features and functional groups, which could potentially target specific biological receptors or enzymes. However, further research and testing would be necessary to determine its specific uses and potential benefits.

InChI:InChI=1/C26H25Cl2FN8/c1-2-36-7-5-20(6-8-36)37-15-19(34-35-37)14-31-18-9-21-25(33-17-3-4-24(29)22(27)10-17)16(12-30)13-32-26(21)23(28)11-18/h3-4,9-11,13,15,20,31H,2,5-8,14H2,1H3,(H,32,33)

Upstream product

• 915364-18-0 6-amino-8-chloro-4-((3-chloro-4-fluorophenyl)amino)quinoline-3-carbonitrile 
• 1175146-85-6 C₁₀H₁₆N₄O 

Relevant articles and documents

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-α (TNF-α) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-4-ylmethyl)-a