915369-61-8

Basic information

• Product Name: 4-hydroxy-7-methyl-6-nitroquinoline-3-carbonitrile
• Synonyms: 4-Hydroxy-7-methyl-6-nitrochinolin-3-carbonitril; 7-Methyl-6-nitro-4-oxo-1,4-dihydrochinolin-3-carbonitril; 7-methyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• CAS NO: 915369-61-8
• Molecular Formula: C₁₁H₇N₃O₃
• Molecular Weight: 229.1916
• Mol File: 915369-61-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 481.1°C at 760 mmHg
• Flash Point: 244.7°C
• Density: 1.5g/cm³
• Vapor Pressure: 7.04E-10mmHg at 25°C
• Refractive Index: 1.701
• CAS DataBase Reference: 4-hydroxy-7-methyl-6-nitroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-7-methyl-6-nitroquinoline-3-carbonitrile(915369-61-8)
• EPA Substance Registry System: 4-hydroxy-7-methyl-6-nitroquinoline-3-carbonitrile(915369-61-8)

Safety Data

• Hazardous Substances Data: 915369-61-8(Hazardous Substances Data)

Upstream product

• 611-05-2 4-nitro-3-methylaniline 

Downstream Products

• 915369-65-2 4-(3-chloro-4-fluoro-phenylamino)-7-methyl-6-nitro-quinoline-3-carbonitrile 
• 915364-01-1 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-7-methylquinoline-3-carbonitrile 

Relevant articles and documents

Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis

The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymatic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered intraperitoneally in mice.