915389-64-9

Upstream product

• 915389-60-5 [(3R,4S)-4-phenyl-1-(trifluoroacetyl)pyrrolidin-3-yl]methanol 
• 915389-62-7 (1R)-1-(1-naphthyl)-N-([(3S,4S)-4-phenyl-1-(trifluoroacetyl)pyrrolidin-3-yl]methyl)ethanamine 
• 300853-88-7 (3R,4S)-3-(([tert-butyl(dimethyl)silyl]oxy)methyl)-4-phenylpyrrolidine 
• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 
• 915389-59-2 (3R,4S)-3-(([tert-butyl(dimethyl)silyl]oxy)methyl)-4-phenyl-1-(trifluoroacetyl)pyrrolidine 

Relevant academic research and scientific papers

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).