91551-59-6

Basic information

• Product Name: 3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE
• Synonyms: [3-(2,6-Dimethylmorpholin-4-yl)propyl]amine;4-MorpholinepropanaMine,2,6-diMethyl-;3-(2,6-dimethyl-4-morpholinyl)propan-1-amine;3-(2,6-dimethylmorpholino)propan-1-amine
• CAS NO: 91551-59-6
• Molecular Formula: C₉H₂₀N₂O
• Molecular Weight: 172.27
• Mol File: 91551-59-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 248.7±25.0 °C(Predicted)
• Appearance: /
• Density: 0.924±0.06 g/cm3(Predicted)
• PKA: 10.33±0.10(Predicted)
• CAS DataBase Reference: 3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE(91551-59-6)
• EPA Substance Registry System: 3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE(91551-59-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 91551-59-6(Hazardous Substances Data)

Usage

General Description

3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE is a chemical compound with the molecular formula C9H18N2O. It is a tertiary amine with a morpholine ring and a propan-1-amine chain. 3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE is commonly used as a building block in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. It has been reported to have a wide range of biological activities, including antifungal, antibacterial, and antiviral properties. Additionally, 3-(2,6-DIMETHYLMORPHOLIN-4-YL)PROPAN-1-AMINE has potential applications in materials science and as a reagent in chemical reactions due to its versatile chemical structure.

Upstream product

• 141-91-3 2,6-dimethyl morpholine 
• 84145-73-3 3-(2,6-Dimethyl-morpholin-4-yl)-propionitrile 

Relevant articles and documents

A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers

A structure-activity relationship study of a series of novel Na+ channel blockers, structurally related to N-[3-(2,6-dimethyl-1-piperidinyl)propyl]- α-phenylbenzeneacetamide (1, PD85639) is described. The diphenylacetic acid portion of the molecule was left unchanged throughout the study, while structural features in the amine portion and the amide alkyl linkage of the molecule were modified. The compounds were tested for inhibition of veratridine-stimulated Na+ influx in CHO cells expressing type IIA Na+ channels. Several derivatives show a trend toward more potent Na+ channel blockade activity with increasing lipophilicity of the amine portion of the molecule. The presence of a phenyl ring near the amine increases inhibitory potency. A three-carbon spacer between the amide and amine is optimal, and a secondary amide linkage is preferred.