915707-07-2

Upstream product

• 3731-16-6 3-carboethoxy-2-pyridone 
• 54555-84-9 benzyl iodoethyl ether 
• 915707-06-1 3-(2-benzyloxyethyl)-2-oxopiperidine-3-carboxylic acid ethyl ester 

Downstream Products

• 943862-54-2 3-[3-{2-benzyloxyethyl}-2-oxo-piperidin-3-yl]-3-oxo-propionic acid ethyl ester 
• 934586-52-4 methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate 
• 934586-57-9 methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate 
• 915706-92-2 3-[3-{2-benzyloxyethyl}-2-oxo-piperidin-3-yl]-3-oxo-propionic acid methyl ester 
• 885043-26-5 3-[1-[2-(1-benzenesulfonyl-1H-indol-3-yl)-acetyl]-3-(2-benzyloxyethyl)-2-oxo-piperidin-3-yl]-2-diazo-3-oxo-propionic acid ethyl ester 
• 885043-25-4 3-[3-{2-benzyloxyethyl}-2-oxo-piperidin-3-yl]-2-diazo-3-oxo-propionic acid ethyl ester 

Relevant academic research and scientific papers

A dipolar cycloaddition approach toward the kopsifoline alkaloid framework

Using a metal-catalyzed domino reaction as the key step, the heterocyclic skeleton of the kopsifoline alkaloid family was constructed by a 1,3-dipolar cycloaddition of a carbonyl ylide dipole derived from a Rh(II)-catalyzed reaction of a diazo ketoester across the indole π-bond. Ring opening of the resulting 1,3-dipolar cycloadduct followed by a reductive dehydroxylation step resulted in the formation of a critical silyl enol ether necessary for the final F-ring closure of the kopsifoline skeleton.

Cycloaddition protocol for the assembly of the hexacyclic framework associated with the kopsifoline alkaloids

(Chemical Equation Presented) An approach to the hexacyclic framework of the kopsifoline alkaloids has been developed and is based on a Rh(II)-catalyzed cyclization-cycloaddition cascade. The resulting [3+2]-cycloadduct was readily converted into the TBS