915720-84-2Relevant academic research and scientific papers
Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones
Boros, Eric E.,Johns, Brian A.,Garvey, Edward P.,Koble, Cecilia S.,Miller, Wayne H.
, p. 5668 - 5672 (2006)
An efficient synthesis of methyl 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-one-6-carboxylates (8-10 and 16) and 6-carboxamides (17-20) is described. Sub-micromolar enzyme inhibition of HIV integrase was achieved with several carboxamide analogs which were superior to their carboxylic ester congeners.
