915720-95-5

Basic information

• Product Name: 5-[methoxycarbonylacetyl-(3-methylsulfanyl-phenyl)-amino]-thiazole-4-carboxylic acid methyl ester
• CAS NO: 915720-95-5
• Molecular Weight: 380.445
• Mol File: 915720-95-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[methoxycarbonylacetyl-(3-methylsulfanyl-phenyl)-amino]-thiazole-4-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[methoxycarbonylacetyl-(3-methylsulfanyl-phenyl)-amino]-thiazole-4-carboxylic acid methyl ester(915720-95-5)
• EPA Substance Registry System: 5-[methoxycarbonylacetyl-(3-methylsulfanyl-phenyl)-amino]-thiazole-4-carboxylic acid methyl ester(915720-95-5)

Safety Data

• Hazardous Substances Data: 915720-95-5(Hazardous Substances Data)

Upstream product

• 51333-80-3 1-isothiocyanato-3-methylsulfanylbenzene 
• 915720-86-4 5-(3-methylsulfanyl-phenylamino)-thiazole-4-carboxylic acid methyl ester 
• 37517-81-0 3-chloro-3-oxopropanoic acid methyl ester 

Downstream Products

• 915721-28-7 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid 4-fluoro-benzylamide 
• 915721-05-0 7-hydroxy-4-(3-methylsulfanyl-phenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones

An efficient synthesis of methyl 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-one-6-carboxylates (8-10 and 16) and 6-carboxamides (17-20) is described. Sub-micromolar enzyme inhibition of HIV integrase was achieved with several carboxamide analogs which were superior to their carboxylic ester congeners.