91575-25-6 Usage
Uses
Used in Biomedical Research:
ARG-GLY-ASP-SER-PRO-ALA-SER-SER-LYS-PRO is used as a test peptide for studying its effect on the adhesion of Hemophilus somnus in bovine brain endothelial cells. This application is crucial for understanding the interaction between this peptide and the bacteria, which may have implications for developing treatments or preventative measures against Hemophilus somnus infections in cattle.
Biochem/physiol Actions
Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro peptide comprises the RGD sequence and blocks β2-integrin-binding sites.
Check Digit Verification of cas no
The CAS Registry Mumber 91575-25-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,5,7 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 91575-25:
(7*9)+(6*1)+(5*5)+(4*7)+(3*5)+(2*2)+(1*5)=146
146 % 10 = 6
So 91575-25-6 is a valid CAS Registry Number.
InChI:InChI=1/C40H68N14O16/c1-20(31(61)50-24(17-55)35(65)51-25(18-56)34(64)49-22(8-2-3-11-41)37(67)54-14-6-10-28(54)39(69)70)47-36(66)27-9-5-13-53(27)38(68)26(19-57)52-33(63)23(15-30(59)60)48-29(58)16-46-32(62)21(42)7-4-12-45-40(43)44/h20-28,55-57H,2-19,41-42H2,1H3,(H,46,62)(H,47,66)(H,48,58)(H,49,64)(H,50,61)(H,51,65)(H,52,63)(H,59,60)(H,69,70)(H4,43,44,45)
91575-25-6Relevant academic research and scientific papers
Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation
Parkhouse, Susan M.,Garnett, Martin C.,Chan, Weng C.
, p. 6641 - 6650 (2008/12/21)
Two new methods for the modular synthesis of targeted gene delivery systems are reported. The PEGylated polyamidoamine DMEDA-PEG-DMEDA-(MBA-DMEDA)n+1-PEG-DMEDA 3 was sequentially modified to contain an integrin-binding peptide ligand via the Staudinger ligation. The conjugation of the ligand was achieved either before particle complexation (precomplexation) or after particle complexation (postcomplexation). Comparison of the two systems showed that postcomplexation strategy led to small and discrete toroidal nanoparticles whilst the precomplexation particles showed loose complexes. The targeted particles showed an increased uptake into cells compared to unmodified complexes however no significant increase in transfection was seen.
