915795-05-0

Usage

Uses

Used in Organic Synthesis:
(-)-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane is used as a building block or intermediate in organic synthesis for the production of various compounds.
Used in Medicinal Chemistry:
(-)-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane is used as a building block or intermediate in the development of pharmaceuticals and other bioactive compounds.
Used in Drug Development:
(-)-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane may have potential applications in the development of new drugs and biologically active molecules due to its unique structure and properties.

Upstream product

• 915302-80-6 tert-butyl (5-benzyl-7-methyl-4-oxo-5-azaspiro[2.4]hept-7-yl)carbamate 
• 915302-78-2 tert-butyl (7-methyl-4-oxo-5-azaspiro[2.4]hept-7-yl)carbamate 
• 915795-01-6 7-amino-7-methyl-5-azaspiro[2.4]heptan-4-one 
• 915794-99-9 1-(1,2-diamino-1-methylethyl)-1-cyclopropanecarboxylic acid tert-butyl ester 
• 915867-73-1 1-(1,2-diamino-1-methylethyl)-1-cyclopropanecarboxylic acid 
• 915794-98-8 1-(1-amino-1-cyanoethyl)-1-cyclopropanecarboxylic acid tert-butyl ester 
• 102540-66-9 tert-butyl 1-acetylcyclopropane-1-carboxylate 
• 915302-85-1 (+)-(7R)-7-amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane 
• 1026452-72-1 C₁₅H₂₂N₂ 
• 915303-01-4 (7S)-7-methyl-4-oxo-5-[(1R)-phenylethyl]-5-azaspiro[2.4]heptane-7-carboxylic acid 
• 915303-00-3 tert-butyl (7S)-7-methyl-4-oxo-5-[(R)-1-phenylethyl]-5-azaspiro[2.4]heptan-7-carboxylate 
• 915302-98-6 tert-butyl (3S)-4-(2-hydroxyethyl)-3-methyl-5-oxo-1-[(R)-1-phenylethyl]pyrrolidine-3-carboxylate 
• 915302-95-3 tert-butyl (3S)-3-methyl-5-oxo-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl- 5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens(1)

Novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)- 2-fluorocyclopropyl]- 8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 2a and 2b were designed and synthesized to obtain potent antibacterial drugs for the treatment of respi

HYDRATE FOR MEDICAL PURPOSES

The present invention relates to [7-[(7S)-7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hemihydrate. This hemihydrate is stable and easy to prepare, and has exc

METHOD FOR PRODUCTION OF QUINOLONE-CONTAINING LYOPHILIZED PREPARATION

The present invention is directed to a lyophilized preparation which contains a synthetic quinolone antibacterial compound and, as a solo additive, a pH-adjusting agent, and which exhibits an excellent reconstituting property. The invention provides a met

PROCESS FOR PREPARATION OF TETRASUBSTITUTED 5-AZASPIRO[2.4]- HEPTANE DERIVATIVES AND OPTICALLY ACTIVE INTERMEDIATES THEREOF

The invention provides a process for effective preparation of optical isomers of tetrasubstituted 5-azaspiro[2.4]heptane derivatives which are useful as intermediates in the preparation of quinolonecarboxylic acid derivative type antimicrobials; and intermediates thereof. The invention relates to a process for the preparation of compounds (VII) according to the following reaction formula: I II’ II (III) IV V VI VII.

TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES

It is intended to provide quinolone type synthetic antibacterial agents having a potent antibacterial activity against a broad scope of gram-positive and gram-negative bacteria and a high safety and remedies for infections. A compound represented by the following general formula (I), its salt or hydrate thereof: I wherein R1 and R2 represent each hydrogen, etc.; R3 represents C1-6 alkyl, etc.; R4 and R5 independently represent each hydrogen, C1-6 alkyl, etc., provided that R4 and R5 are not hydrogen atoms at the same time, and the above substituents R4 and R5 may be united and form a spiro ring structure structure together with the pyrrolidine ring; R6 and R7 independently represent each hydrogen or C1-6 alkyl; R8 represents a C1-6 haloalkyl group, etc.; X1 represents hydrogen or halogen; and A represents a nitrogen atom or a partial structure represented by the following general formula (II).

METHOD FOR PRODUCING ASYMMETRIC TETRASUBSTITUTED CARBON ATOM-CONTAINING COMPOUND

Disclosed is a method for commercially producing a spiroaminopyrrolidone derivative as an intermediate for a quinolone antibacterial agent. Specifically disclosed is a method for producing a compound represented by the formula (2) below wherein a compound

Tri-, tetra-substituted-3-aminopyrrolidine derivative

A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria, and which are also highly safe are provided. The compound provided is represented by following formula (I): wherein R1 and R2 represent hydrogen atom, or the like; R3 represents an alkyl group containing 1 to 6 carbon atoms, or the like; R4 and R5 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like, with the proviso that R4 and R5 do not simultaneously represent hydrogen atom; or the substituents R4 and R5 together represent (a) a 3- to 6-membered cyclic structure including the carbon atom shared by R4 and R5 to form a spirocyclic structure with the pyrrolidine ring; R6 and R7 independently represents hydrogen atom, an alkyl group containing 1 to 6 carbon atoms, or the like; R8 represents a halogen-substituted alkyl group containing 1 to 6 carbon atoms, or the like; X1 represents hydrogen atom or a halogen atom; A represents nitrogen atom or a moiety represented by formula (II):